Results 51 to 60 of about 7,615,514 (366)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Managing xylazine-involved overdoses in a community harm reduction setting: lessons from Tijuana, Mexico

Harm Reduction Journal
Background Xylazine is a α2-adrenergic receptor agonist, used for sedation in veterinary contexts. Although it is increasingly found in overdose deaths across North America, the clinical management of xylazine-involved overdoses has not been extensively ...
Lilia Pacheco Bufanda, Alejando González Montoya, Brenda Torres Carrillo, Mariana Alejandra Gonzalez Tejeda, Luis A. Segovia, Alhelí Calderón-Villarreal, Joseph R. Friedman   +6 more
doaj   +1 more source

Voltage Distribution and Flashover Performance of 220 kV Composite Insulators under Different Icing Conditions

Energies, 2018
Composite insulators are widely used in modern power systems to provide electrical insulation and mechanical support for transmission lines and substations.
Jiazheng Lu, Pengkang Xie, Zhenglong Jiang, Zhen Fang, Wei Wu   +4 more
doaj   +1 more source

Dimensionality Reduction Mappings [PDF]

, 2011
A wealth of powerful dimensionality reduction methods has been established which can be used for data visualization and preprocessing. These are accompanied by formal evaluation schemes, which allow a quantitative evaluation along general principles and ...
Hammer, Barbara ; https://orcid.org/, Hammer, Barbara,, Kerstin Bunte, Michael Biehl, Bunte, Kerstin; id_orcid, Bunte, Kerstin,, Barbara Hammer, Biehl, Michael, Bunte, Kerstin, Biehl, Michael,, Biehl, Michael; id_orcid, IEEE Computational Intelligence Society, Hammer, Barbara   +12 more
core   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Neo-colonialism and financing for the war on drugs: a review of current policy and recommendations for countries in the global north

Harm Reduction Journal
Globally, punitive drug control upholds racist and colonial structures. Marginalised and racialised communities, including Indigenous peoples, are disproportionately targeted and affected by punitive drug policy in law enforcement, judicial and carceral ...
Colleen Daniels, Naomi Burke-Shyne, Catherine Cook, Anoushka Beattie   +3 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Why community-based disaster risk reduction fails to learn from local knowledge? Experiences from Malawi [PDF]

, 2022
This contributing paper aims to investigate the extent to which community-based disaster risk reduction (CBDRR) in practice really takes into account local knowledge (LK).
Sakic Trogrlic, R., Adeloye, A., Mwale, F., Duncan, M., Wright, G., van den Homberg, M.   +5 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

MANTRA: development and localization of a mobile educational health game targeting low literacy players in low and middle income countries

BMC Public Health, 2020
Background Mobile technology is increasingly important for delivering public health interventions to remote populations. This research study developed, piloted, and assessed a serious game for mobile devices that teaches geohazard, maternal, and neonatal
Sonja Mueller, Delphine Soriano, Andrei Boscor, Naomi Saville, Abriti Arjyal, Sushil Baral, Maureen Fordham, Gareth Hearn, Virginie Le Masson, Rachya Kayastha, Patty Kostkova   +10 more
doaj   +1 more source