Results 181 to 190 of about 776,097 (338)

The crisis of scientific paradigm in modern psychiatry and a look to the future. [PDF]

PCN Rep
Levín SA.
europepmc   +1 more source

77. Cathodic Reduction of Oxygen in Molten Alkali Carbonates – Part 3. Chemically Dissolved Oxygen Species in (Li/Na), (Li/K), and (Li/Na/K) Molten Carbonates –

, 2005
Minoru Takahashi, Noboru Masuko
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Geneticization in the genomic era: a scoping review of ethical, clinical, and sociocultural transformations. [PDF]

Front Sociol
Shaheen S, Ghaly M.
europepmc   +1 more source

Reduction of flatfish habitat as a consequence of the proliferation of an invasive mollusc

, 2011
C. Kostecki, S. Rochette, R. Girardin, M. Blanchard, N. Desroy, O. Le Pape   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Why inflammatory reductionism is a threat to psychiatry (and the rest of medicine). [PDF]

Brain
Pollak TA.
europepmc   +1 more source

Dataset and figures related to "Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model" preprint (Lucas Del-Pozo & Uras et al., 2023)

, 2023
Lucas-Del-Pozo, Sara, Uras, Giuseppe, Fierli, Federico, Lentini, Veronica, Koletsi, Sofia, Chau, Kai-Yin, Hughes, Derralynn, Schapira, Anthony   +7 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Reimagining patient-reported outcomes in the age of generative AI. [PDF]

NPJ Digit Med
Boyer L, Fernandes S, Auquier P, Falissard B, Panch T.   +4 more
europepmc   +1 more source