Results 61 to 70 of about 67,395 (285)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
METAPHYSICAL REVOLUTION OF DESCARTES AND TRANSFORMATION OF THE ANTHROPOLOGICAL PROJECT
Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2015 The purpose is to reveal and comprehend forms of influence metaphysical' revolution for a way of interpretation of the anthropological project by Descartes on the basis of investigations of modern dekartes's researchers, that is the recognition of a ...
Anatolii M. Malivskyi
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The GSSP Method of Chronostratigraphy: A Critical Review
Frontiers in Earth Science, 2018 The use of boundary stratotypes to define chronostratigraphic units began in the 1960s, and, in the 1980s, these were called Global Stratotype Sections and Points (GSSPs). Approximately two-thirds of the GSSPs of the bases of the Phanerozoic stage (71 of
Spencer G. Lucas
doaj +1 more source
The place of experiment in the mind-brain sciences
Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας, 2020 IS AVAILABLE IN THE ...
A. K. Moschovakis
doaj +1 more source
Salis est: Ecumenical Catalyst or Narrow Reductionism? [PDF]
, 2003 (Excerpt) It is also taught among us that one holy Christian church will be and remain focever. This is the assembly of all believers [or saints ] among whom the Gospel is preached in its purity and the holy sacraments are administered according to the ...
Johnson, Maxwell E
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Writing biology with mutant mice: the monstrous potential of post genomic life [PDF]
, 2011 Social scientific accounts identified in the biological grammars of early genomics a monstrous reductionism, ‘an example of brute life, the minimalist essence of things’ (Rabinow, 1996, p. 89).
Davies, GF
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source