Results 81 to 90 of about 12,850 (294)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Física e biologia: possíveis limites de demarcação conceitual Possible limits of conceptual demarcation

open access: yesTrans/Form/Ação, 2006
A partir do texto do físico alemão E.Schroedinger, O que é vida? (1943), analisam-se os possíveis limites de demarcação conceitual entre física e biologia. Há um limite possível entre física e biologia? Ou a biologia pode ser reduzida à física?
Arthur Araújo
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Łukasiewicz and Quine on Empirical and A Priori Sciences

open access: yesStudia Semiotyczne, 2020
DOI: http://doi.org/10.26333/sts.xxxiii2.07 Although Łukasiewicz and Quine do not share many common views, they agreed on one important point in the 1950s: they both denied the distinction between empirical and a priori sciences.
Zuzana Rybaříková
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

RECIPIENT FACTOR IN POETIC TRANSLATION DIACHRONY

open access: yesRUDN Journal of Language Studies, Semiotics and Semantics, 2019
The paper's aim is to analyze transchronical interlingual and intercultural poetic communication. Special attention is paid to the recipient, his significance in diachronic translation is investigated.
Irina Nikolaevna Filippova
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

BIOETIKA DALAM PERSPEKTIF ISLAM SEBAGAI PENGAWAL PERKEMBANGAN BIOLOGI MODERN

open access: yesUlul Albab, 2013
Modern biology has been developing so rapidly that the field can amazingly provides great benefits for human beings’ prosperous life either at present or in the future.
Eko Budi Minarno
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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