Results 81 to 90 of about 17,601 (278)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Łukasiewicz and Quine on Empirical and A Priori Sciences
Studia Semiotyczne, 2020 DOI: http://doi.org/10.26333/sts.xxxiii2.07 Although Łukasiewicz and Quine do not share many common views, they agreed on one important point in the 1950s: they both denied the distinction between empirical and a priori sciences.
Zuzana Rybaříková
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
RECIPIENT FACTOR IN POETIC TRANSLATION DIACHRONY
RUDN Journal of Language Studies, Semiotics and Semantics, 2019 The paper's aim is to analyze transchronical interlingual and intercultural poetic communication. Special attention is paid to the recipient, his significance in diachronic translation is investigated.
Irina Nikolaevna Filippova
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emergence, Reduction and Supervenience: a Varied Landscape [PDF]
, 2010 This is one of two papers about emergence, reduction and supervenience. It expounds these notions and analyses the general relations between them. The companion paper analyses the situation in physics, especially limiting relations between physical ...
Butterfield, Jeremy, J. Butterfield
core +1 more source
BIOETIKA DALAM PERSPEKTIF ISLAM SEBAGAI PENGAWAL PERKEMBANGAN BIOLOGI MODERN
Ulul Albab, 2013 Modern biology has been developing so rapidly that the field can amazingly provides great benefits for human beings’ prosperous life either at present or in the future.
Eko Budi Minarno
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Ostium, 2017 History of philosophy offers many examples capable of informing discussions related to questions, topics and problems, which are actual for both philosophy and particular scientific fields. Explanation of the nature of life is such a topic.
Vladimír Vodička
doaj