Results 91 to 100 of about 5,134,770 (327)
Methodology Integration in Human Medical Study
Proceedings, 2017 Due to numerous factors two categories of methodology in scientific studies have been established till the present time, one for classical physics and the other for information science, each of which have been successful in its own domain.
Yixin Zhong
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Who are we as historical beings? Shaping identities in light of the archaeogenetics ‘revolution’
Current Swedish Archaeology, 2019 There is a human fundamental need to know who we are and where we come from. In an age when myths, legends and family memories are starting to fade or become obsolete, science is brought in to fill the gaps and answer these questions.
Alexandra Ion
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
The Limits of Reductionism in Medicine: Could Systems Biology Offer an Alternative?
PLoS Medicine, 2006 In the first of a two part series, Ahn and colleagues discuss the reductionist approach pervading medicine and explain how a systems approach (as advocated by systems biology) may complement reductionism.
Andrew C Ahn +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Darwin and Reductionisms: Victorian, Neo-Darwinian and Postgenomic Biologies
19, 2010 This article compares the open-ended Darwinism of Charles Darwin, George Lewes, George Eliot and Thomas Hardy with reductive post-Weismann and early eugenist views and more recent neo-Darwinian ideas including literary Darwinism.
Angelique Richardson
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Desk study on homeopathy in organic livestock farming: Principles, obstacles and recommendations for practice and research [PDF]
, 2003 Organic livestock farming has its own concept of health and welfare. The approach to health can be characterised by the key words human, preventive, self-regulating and holistic (Chapter 1).
Baars, Erik +3 more
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source