Results 111 to 120 of about 12,850 (294)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
To defend mereological reductionism from 2 objections
, 2011 In this paper, I will deal with what mereological reductionism is, what problem occurs if we accept mereological reductionism and how we could avoid the objections against mereological reductionism.
Lee, Jun-hyo
core
Consciousness in Evolution: Sketch for a New Model – A Speculation [PDF]
Integral Review, 2009 It is hypothesized that hierarchically negentropic systems (defined herein), including organisms, are associated with partially non-local information/probability fields which, a) entail or express interiority, b) engender “entangled learning” with ...
Donald F. Padelford
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Phenomenal intentionality: reductionism vs. primitivism
, 2018 This paper explores the relationship between phenomenal properties and intentional properties. In recent years a number of philosophers have argued that intentional properties are sometimes necessitated by phenomenal properties, but have not explained ...
Philip Woodward, Woodward, Philip
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Reductionism and library and information science philosophy
, 2008 Purpose: The purpose of this article is to consider the meaning of 'reductionism' within the context of renewed efforts to make library and information science philosophy. Design/methodology/approach: This article argues that the question of reductionism,
Bonna Jones (19117708)
core
What lies beyond reductionism? Taking stock of inter-disciplinary research on ecological economics
, 2013 This contribution is intended to give the reader a feeling for the general subject of interdisciplinary research concerning social-ecological systems and relationships, and to highlight the challenges that its practitioners can expect to face, and do ...
Farrell K. N +2 more
core +1 more source