Results 101 to 110 of about 5,134,770 (327)

Psychophysical Nature [PDF]

open access: yes, 2007
There are two quite distinct ways in which events that we normally think of as “physical” relate in an intimate way to events that we normally think of as “psychological”.
Velmans, Prof Max
core  

Resisting reductionism in mathematics pedagogy

open access: yesCurriculum Journal, 2013
Although breaking down a mathematical problem into smaller parts can often be an effective solution strategy, when the same reductionist approach is applied to mathematics pedagogy the effects are far from beneficial for students. Mathematics pedagogy in
Colin Foster
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Subjective Evolution of Consciousness in Modern Science and Vedāntic Philosophy: Particulate Concept to Quantum Mechanics in Modern Science and Śūnyavāda to Acintya-Bhedābheda-Tattva in Vedānta [PDF]

open access: yes, 2019
How the universe came to be what it is now is a key philosophical question. The hypothesis that it came from nothing or śūnya (as proposed by Stephen Hawking, among others) proves to be dissembling, since the quantum vacuum can hardly be considered a ...
Ph D. Shanta, PhD
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Física e biologia: possíveis limites de demarcação conceitual Possible limits of conceptual demarcation

open access: yesTrans/Form/Ação, 2006
A partir do texto do físico alemão E.Schroedinger, O que é vida? (1943), analisam-se os possíveis limites de demarcação conceitual entre física e biologia. Há um limite possível entre física e biologia? Ou a biologia pode ser reduzida à física?
Arthur Araújo
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Łukasiewicz and Quine on Empirical and A Priori Sciences

open access: yesStudia Semiotyczne, 2020
DOI: http://doi.org/10.26333/sts.xxxiii2.07 Although Łukasiewicz and Quine do not share many common views, they agreed on one important point in the 1950s: they both denied the distinction between empirical and a priori sciences.
Zuzana Rybaříková
doaj  

From Reductionism to Holism: Systems-oriented Approaches in Cancer Research

open access: yesGlobal Advances in Health and Medicine, 2012
Somatic mutation theory of cancer has directed cancer research during the last century. A deluge of information on cellular, molecular, and genetic behavior was uncovered, but so was a mind-numbing complexity that still challenges research and concepts ...
G. Kienle, H. Kiene
semanticscholar   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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