Results 31 to 40 of about 258,017 (310)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Design and Implementation of Beidou Differential Positioning Scheme for Train Control System
Kongzhi Yu Xinxi Jishu, 2020 Accurate locomotive position is a prerequisite for train operation control and the existing locomotive positioning technology has the problems such as poor positioning accuracy, high investment cost and maintenance difficulties.
WANG Yeliu, BAI Changlong, XIAO Lizhi
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
On the Exact Reliability Enhancements of Small Hammock Networks
IEEE Access, 2018 In this paper, we study small hammock networks, more precisely the 29 hammock networks presented by Moore and Shannon in their prescient paper from 1956, where this type of network was introduced.
Simon R. Cowell +3 more
doaj +1 more source
IET Generation, Transmission & Distribution, 2023 This paper proposes an economical reliability‐oriented solution to determine the optimal number of cascade cells and redundancies for STATCOM using a Non‐Dominated Sorting Genetic (NSGA‐II) algorithm based on different redundancy configuration schemes. A
Maede Azimi, Mehdi Asadi
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
EFFICIENCY OF REDUNDANT SYSTEM THROUGH CONFIGURATION SUPERVISORS
Надежность и качество сложных систем, 2022 Background. The path to the creation of highly reliable equipment, each separate part of which, due to several factors, has limited reliability, is to develop reconfigurable systems with an excessive number of heterogeneous components. The objective of
А.М. Ageev, V.N. Bukov
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Numbers on Thematic Maps: Helpful Simplicity or Too Raw to Be Useful for Map Reading?
ISPRS International Journal of Geo-Information, 2020 As the development of small-scale thematic cartography continues, there is a growing interest in simple graphic solutions, e.g., in the form of numerical values presented on maps to replace or complement well-established quantitative cartographic methods
Jolanta Korycka-Skorupa +1 more
doaj +1 more source