Results 41 to 50 of about 258,393 (219)

Improved Measures of Redundancy and Relevance for mRMR Feature Selection

open access: yesComputers, 2019
Many biological or medical data have numerous features. Feature selection is one of the data preprocessing steps that can remove the noise from data as well as save the computing time when the dataset has several hundred thousand or more features ...
Insik Jo, Sangbum Lee, Sejong Oh
doaj   +1 more source

The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

open access: yeseLife, 2021
Gene regulation via N6-methyladenosine (m6A) in mRNA involves RNA-binding proteins that recognize m6A via a YT521-B homology (YTH) domain. The plant YTH domain proteins ECT2 and ECT3 act genetically redundantly in stimulating cell proliferation during ...
Laura Arribas-Hernández   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

The effect of multiple natural enemies on a shared herbivore prey

open access: yesEcology and Evolution, 2019
Natural enemy diversity is thought to be important for effective suppression of herbivores in production systems. Studies investigating the importance of the diversity and composition of the natural enemy complex often use within‐year empirical studies ...
Maartje J. Klapwijk
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Fault-tolerant method for anti-SEU of embedded system based on dual-core processor

open access: yesThe Journal of Engineering, 2019
The development of space applications based on commercial system on chip (SOC) FPGA devices has become an important direction for the development of aerospace technology, but single event upsets (SEUs) in space is a difficult problem for commercial SOC ...
Xiuhai Cui   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

REFLECTIONS ON PLEONASM AND TAUTOLOGY [PDF]

open access: yesStudiul Artelor şi Culturologie: Istorie, Teorie, Practică, 2019
In the linguistic literature, we have repeatedly talked about pleonasm as a mistake of expression. However, it is still attested in current speech, in the press, and beyond. In this article, we will analyze some common cases in which the pleonasm appears,
DODON EUGENIA
doaj  

Dynamic partial reconfiguration scheme for fault-tolerant FFT processor based on FPGA

open access: yesThe Journal of Engineering, 2019
The fast Fourier transform FFT processor is an important part of the space real-time signal processing system based on field programmable gate array (FPGA).
Xin Wei, Yi Z Xie, Yu Xie, He Chen
doaj   +1 more source

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