Results 61 to 70 of about 776,492 (298)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2015 The purpose of this paper is to present solution to an ill-posed problem for a muscular internal force feedforward positioning method of a musculoskeletal system. In our previous research, the muscular internal force feedforward positioning method of the
Yuki MATSUTANI +4 more
doaj +1 more source
The Virtues of Redundancy in Legal Thought [PDF]
, 1990 Redundancy has a bad reputation among legal intellectuals. When someone says, for example, that the ninth and tenth amendments are redundant, we can be pretty sure that this person attaches little importance to these constitutional provisions.
Barnett, Randy E
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Improved Measures of Redundancy and Relevance for mRMR Feature Selection
Computers, 2019 Many biological or medical data have numerous features. Feature selection is one of the data preprocessing steps that can remove the noise from data as well as save the computing time when the dataset has several hundred thousand or more features ...
Insik Jo, Sangbum Lee, Sejong Oh
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Tight Bounds for Gomory-Hu-like Cut Counting
, 2016 By a classical result of Gomory and Hu (1961), in every edge-weighted graph $G=(V,E,w)$, the minimum $st$-cut values, when ranging over all $s,t\in V$, take at most $|V|-1$ distinct values.
Chitnis, Rajesh +2 more
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Slice group based multiple description video coding with three motion compensation loops [PDF]
, 2005 The paper proposes a novel scheme for a multiple description video coding approach using the slice group coding tool proposed in H.264. Three motion compensation loops, one central and two side loops, are maintained for two descriptions in the encoder ...
Bull, DR, Canagarajah, CN, Wang, D
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
The effect of multiple natural enemies on a shared herbivore prey
Ecology and Evolution, 2019 Natural enemy diversity is thought to be important for effective suppression of herbivores in production systems. Studies investigating the importance of the diversity and composition of the natural enemy complex often use within‐year empirical studies ...
Maartje J. Klapwijk
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