Results 41 to 50 of about 94,442 (173)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Timing behavior of the Magnetically Active Rotation-Powered Pulsar in the Supernova Remnant Kestevan 75

, 2010
We report a large spin-up glitch in PSR J1846-0258 which coincided with the onset of magnetar-like behavior on 2006 May 31. We show that the pulsar experienced an unusually large glitch recovery, with a recovery fraction of Q=8.7+/- 2.5, resulting in a ...
Alpar, Alpar, Archibald, Beloborodov, Camilo, Camilo, Chatterjee, Dall’Osso, Dib, Dib, Fotis. P. Gavriil, Gavriil, Gavriil, Gonzalez, Gotthelf, Halpern, Helfand, Helfand, Ibrahim, Israel, Jahoda, Kaspi, Kaspi, Kaspi, Kuiper, Kumar, Leahy, Livingstone, Livingstone, Lohsen, Lyne, Manchester, Margaret A. Livingstone, Ng, Peralta, Shemar, Su, Thompson, Thompson, Thompson, Victoria M. Kaspi, Wong, Woods, Woods, Zhu   +44 more
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Polar and magnetic order in GaV4Se8

, 2017
In the present work, we provide results from specific heat, magnetic susceptibility, dielectric constant, ac conductivity, and electrical polarization measurements performed on the lacunar spinel GaV4Se8.
Butykai, A., Geirhos, K., Kézsmárki, I., Loidl, A., Lunkenheimer, P., Ruff, E., Stefanet, E., Tsurkan, V., Widmann, S.   +8 more
core   +1 more source

Research on Referees of Indoor Sports Exposed to Mobbing Behaviors in Their Classes in Turkey

The Anthropologist, 2015
The aim of this study is to identify the level of mobbing behaviors that referees of indoor sports are exposed to in terms of some demographic variables in Turkey and raise awareness on this issue....
openaire   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Relative twisting in Outer space

, 2012
Subsurface projection has become indispensable in studying the geometry of the mapping class group and the curve complex of a surface. When the subsurface is an annulus, this projection is sometimes called relative twisting.
Clay, Matt, Pettet, Alexandra
core   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Constructing Regularized Cosmic Propagators

, 2012
We present a new scheme for the general computation of cosmic propagators that allow to interpolate between standard perturbative results at low-k and their expected large-k resummed behavior.
Bernardeau, Francis, Crocce, Martin, Scoccimarro, Roman   +2 more
core   +1 more source

High prevalence of tobacco-related risky behaviors among amateur rugby players, coaches and referees: It is time to act!

Archives of Cardiovascular Diseases Supplements, 2020
Background High prevalence of smoking has been documented in France and new worrying patterns of tobacco and nicotine consumption are emerging, especially in some sports. Purpose We addressed tobacco consumption and their related-risk knowledge across the whole spectrum of amateur rugby practice in a French region, i.e. players (P), coaches(C) and
Frédéric Chagué, J.C. Dincher, J. Israël, E. Reboursière, G. Garet, M. Georges, P. Ngassa, J.P. Guinoiseau, J.P. Hager, Marianne Zeller, Yves Cottin, M. Geneste   +11 more
openaire   +2 more sources