Results 91 to 100 of about 1,275,125 (288)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Topic Map Generation Using Text Mining [PDF]

open access: yes, 2002
Starting from text corpus analysis with linguistic and statistical analysis algorithms, an infrastructure for text mining is described which uses collocation analysis as a central tool.
Böhm, Karsten   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

What effect does transition have on health and well-being in young people with intellectual disabilities? A systematic review [PDF]

open access: yes, 2016
Background: Transition to adulthood might be a risk period for poor health in people with intellectual disabilities. However, we could find no synthesis of evidence on health and wellbeing outcomes during transition in this population.
Cooper, Sally-Ann   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Automation of update of digital national geo‐reference databases / Nacionalinių georeferencinių duomenų bazių atnaujinimo automatizavimas

open access: yesTechnological and Economic Development of Economy, 2010
Unified geo‐reference data model is a very important part of national geographic information management. It has been developed within the project of Lithuanian geographic information infrastructure in 2006–2008. This model allows automated integration of
Žilvinas Stankevičius   +2 more
doaj   +1 more source

German Vegetation Reference Database (GVRD) [PDF]

open access: yesBiodiversity & Ecology, 2012
The German Vegetation Reference Database (GVRD; GIVD ID EU-DE-014) was established in 2008 as a reference vegetation database for vegetation records of the German Biodiversity Exploratories (http://www.biodiversity-exploratories.de/). Initially, the database had a focus on forest and grassland vegetation but is currently undergoing a continuous ...
Ute Jandt, Helge Bruelheide
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

A deep learning pipeline for product recognition on store shelves

open access: yes, 2018
Recognition of grocery products in store shelves poses peculiar challenges. Firstly, the task mandates the recognition of an extremely high number of different items, in the order of several thousands for medium-small shops, with many of them featuring ...
Di Stefano, Luigi   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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