Results 91 to 100 of about 5,500,427 (306)

Fugu: a compact vertebrate reference genome [PDF]

FEBS Letters, 2000
At 400 Mb, the Japanese pufferfish, Fugu rubripes, has the smallest vertebrate genome but has a similar gene repertoire to other vertebrates. Its genes are densely packed with short intergenic and intronic sequences devoid of repetitive elements. It likely has a mutational bias towards DNA elimination and is probably close to a ‘minimal’ vertebrate ...
Venkatesh, Byrappa, Gilligan, Patrick, Brenner, Sydney   +2 more
openaire   +2 more sources

Bioinformatics' approaches to detect genetic variation in whole genome sequencing data [PDF]

, 2010
Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core  

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons [PDF]

, 2011
Background Visualisation of genome comparisons is invaluable for helping to determine genotypic differences between closely related prokaryotes. New visualisation and abstraction methods are required in order to improve the validation, interpretation and
Beatson, SA, Beatson Scott A, Nabil-Fareed Alikhan, Ben Zakour, Nouri L., Beatson, Scott A., Petty, NK, Nicola K Petty, Petty Nicola K, Alikhan Nabil-Fareed, Alikhan, Nabil-Fareed, Petty, Nicola K., Ben Zakour, NL, Scott A Beatson, Alikhan, NF, Nouri L Ben Zakour, Ben Zakour Nouri L   +15 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Complete mitochondrial genomes of Bos taurus and Bos indicus provide new insights into intraspecies variation taxonomy and domestication [PDF]

, 2008
The taurine and zebuine cattle breeds comprise the majority of the world cattle population but their taxonomic status is still controversial. The two forms of cattle are currently classified as Bos taurus and Bos indicus species and are differentiated ...
Janke, Axel, Janke, A., Lewalski, H., Hiendleder, S, Lewalski, H, Hiendleder, S.   +5 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Draft genome sequence of shiga toxin-producing Escherichia coli Strain D92/09

, 2015
Escherichia coli is suspected to be involved with Crohn's disease. Adherence and invasion to epithelial cells are properties commonly observed in these bacteria. Here, we present a draft genome sequence of E.
Santos, Ana Carolina da Silva, Rodrigues, Josias, Da Silva Santos, Ana Carolina, Da Silva Santos, Ana Carolina [UNESP], Rodrigues, Josias [UNESP], Santos, Ana Carolina da Silva [UNESP]   +5 more
core   +1 more source

Reciprocal Genome Projection Reveals Reference-Conditioned Functional Variation in Clinical Aspergillus Section Nigri Isolates

Pathogens
Closely related Aspergillus section Nigri species are difficult to resolve taxonomically, while short-read comparisons may be influenced by reference-genome choice.
Siphiwengesihle Kuhle Silindile Mbamali, Nikwando Mohlomi, Magriet van der Nest, Nokuthula Peace Mchunu, Kugenthiren Permaul   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Predicted chemosensory proteins, odorant binding proteins and olfactory receptors in the H. melpomene reference genome

, 2015
The data file contains putative coding and amino acid sequences for the chemosensory protein (CSP), odorant binding protein (OBP) and olfactory receptor (Or) gene families identified in the version 1.1 Heliconius melpomene melpomene reference genome ...
The Heliconius Genome Consortium, The Heliconius Genome Consortium (3375806)   +1 more
core   +1 more source