Results 121 to 130 of about 5,500,427 (306)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceThe genome of the obligate intracellular parasite Trachipleistophora hominis : new insights into microsporidian genome dynamics and reductive evolution [PDF]
, 2012 The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems involving obligate intracellular bacteria.Thomas Weinmaier (124598), Hall, Neil (Department of Functional and Comparative Genomics, School of Biological Sciences, University of Liverpool), Bernhardt Jörg, Robert P Hirt, Hacker Christian, Swan, Daniel C., Robert P. Hirt (124609), Weinmaier, Thomas, Nakjang, Sirintra, Rattei, Thomas, Harris, Simon R. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Noël Christophe J., Noel, Christophe J., Embley, T. Martin, John M. Lucocq (124603), Christian Hacker (124601), Hirt, Robert P. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Christophe J. Noël (124592), Lucocq, John M., Stephanie Markert, Tom A. Williams, Embley T. Martin, Neil Hall, Nakjang Sirintra, Williams Tom A., Sirintra Nakjang (124590), Dagan Tal, Martin Embley, John M Lucocq, Rattei, Thomas (University of Vienna), Goldberg Alina V., Tom A Williams, Dagan, Tal (Institute for Molecular Evolution, Heinrich Heine University Düsseldorf), Lucocq John M., Hall Neil, Bernhardt, Jörg, Heinz Eva, Simon R. Harris, Neil Hall (12782), Lucocq, John M. (School of Medicine, University of St Andrews), Noël, Christophe J. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier, Thomas (University of Vienna), Markert, Stephanie (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Tal Dagan, Daniel C. Swan, Sirintra Nakjang, John M. Lucocq, Dörte Becher, Rattei Thomas, Harris Simon R., Daniel C Swan, Christian Hacker, Thomas Rattei (13991), Becher, Dörte, Swan Daniel C., Heinz, Eva (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Weinmaier Thomas, Eva Heinz, Hacker, Christian, Alina V. Goldberg, Simon R Harris, Christophe J. Noël, Thomas Rattei, Eva Heinz (105025), Swan, Daniel C. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Thomas Weinmaier, Simon R. Harris (124597), Schweder, Thomas (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), T Martin Embley, Becher, Doerte, Harris, Simon R., Hacker, Christian (School of Medicine, University of St Andrews), Alina V. Goldberg (124596), Heinz, Eva, Dagan, Tal, Becher Dörte, Markert, Stephanie, Bernhardt, Jörg (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Goldberg, Alina V. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Schweder Thomas, Hirt, Robert P., T. Martin Embley (124611), Nakjang, Sirintra (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Dörte Becher (90765), Tom A. Williams (124587), Thomas Schweder (124606), Markert Stephanie, Bernhardt, Joerg, Embley, T. Martin (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Williams, Tom A., Hirt Robert P., Alina V Goldberg, Williams, Tom A. (Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University), Jörg Bernhardt (124600), Jörg Bernhardt, Goldberg, Alina V., Schweder, Thomas, Tal Dagan (68513), Robert P. Hirt, Lucocq, John Milton, Hall, Neil, Christophe J Noël, Thomas Schweder, Becher, Dörte (Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald), Daniel C. Swan (124594), Stephanie Markert (124599) +105 morecore +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceStimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi +19 morewiley +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceA complete reference genome of broomcorn millet
Scientific DataAbstractBroomcorn millet (Panicum miliaceum L.), known for its traits of drought resistance, adaptability to poor soil, short growth period, and high photosynthetic efficiency as a C4 plant, represents one of the earliest domesticated crops globally. This study reports the telomere-to-telomere (T2T) gap-free reference genome for broomcorn millet (AJ8 ...Haigang Wang, Junjie Wang, Chunhai Chen, Ling Chen, Meng Li, Huibin Qin, Xiang Tian, Sen Hou, Xukui Yang, Jianbo Jian, Peng Gao, Lun Wang, Zhijun Qiao, Zhixin Mu +13 moreopenaire +3 more sourcesReference genome sequence
, 2016 An original reference genome sequence was downloaded from http://www.beanbeetles.org/genome/denovo/new/longContigs.fasta. We then added GBS consensus sequences that did not match this reference as additional contigs.Messina, Frank J., Gompert, Zachariah, Frank J. Messina (3319107), Zachariah Gompert (195300) +3 morecore +1 more source
