Results 141 to 150 of about 781,120 (260)

A chromosome level reference genome for the pecan weevil, Curculio caryae. [PDF]

Sci Data
Perkin LC, Cohen ZP, Sim SB, Geib SM, Childers AK, Smith TPL, Johnston JS, Saelao P, Suh CP.   +8 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A High-quality Reference Genome and Tissue Expression Atlas for the European Lobster (Homarus gammarus). [PDF]

Genome Biol Evol
Paris JR, Jenkins TL, Ferrer Obiol J, Gundappa MK, Regan T, Campbell L, Maslen GL, Alvarez-Jarreta J, Dyer S, Jeffries AR, Murray G, Farbos A, Bickley LK, Verbruggen B, Bateman KS, Daniels CL, Ellis CD, Ashton TJ, Tyler CR, Stentiford GD, Houston RD, Bean TP, van Aerle R, Macqueen DJ, Stevens JR, Santos EM.   +25 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Chromosome-Level Reference Genome of the Beach False Foxglove, Agalinis fasciculata (Orobanchaceae). [PDF]

Genome Biol Evol
Pezzi PH, Latvis M.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Chromosome-scale reference genome assembly and annotation of Prunus scopulorum. [PDF]

Sci Data
Guo T, Li X, Zhu D, Shen B, Hong P, Zhang L, Sun S, Wang J, Qiao Q, Liu Q.   +9 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A chromosome-level reference genome of an endangered plant Craigia yunnanensis. [PDF]

Sci Data
Cheng Z, Xing Y, Pan Y, Wang J, Wu X, Li J, Xu C, Xu RA, Xia F, Liu Z, Long C.   +10 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source