Results 171 to 180 of about 28,569 (299)

Development of noninformative priors for Bayesian analysis

, 1994
The reference priors, initiated in Bernardo (1979) and further developed in Berger and Bernardo (1992a, b, c), are applied to several statistical models.
Yang, Ruoyong
core  

Data-Limited Stock Status Assessment of Bonga Shad, <i>Ethmalosa fimbriata</i> (Bowdich, 1825) and Lesser African Threadfin, <i>Galeoides decadactylus</i> (Bloch, 1795) in the Central Gulf of Guinea. [PDF]

Biology (Basel)
Atem EE, Kindong R, Ayuk CE, Bayon MS, Mboglen D, Tian S.   +5 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Properly constrained reference priors decay rates for efficient and robust posterior inference

In Bayesian analysis, reference priors are widely recognized for their objective nature. Yet, they often lead to intractable and improper priors, which complicates their application.
Van Biesbroeck, Antoine
core  

Statistical Modeling of Seafood Fraud Highlights Uncertainties in Products From Metro Vancouver, British Columbia, Canada: Revisiting Hu et al. (2018). [PDF]

J Food Sci
Phillips JD, De Vuono-Fraser FA.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Real-Time Edge-Prior Guided SegFormer for Robust Contour Extraction of Aggregate Particles in Conveyor-Belt Depth Maps. [PDF]

Sensors (Basel)
Shen J, Liu H, Chen Z, Zhao X, Yang H.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Probability matching priors: a review

, 1999
In recent years, extensive work has been done concerning the derivation of noninformative prior distributions assuring approximate frequentist validity of Bayesian inferences.This paper provides a review of matching priors obtained via quantiles and via ...
Scricciolo, Catia
core  

Computational blueprints for cell fate programming. [PDF]

Stem Cell Reports
Yang P.
europepmc   +1 more source