Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Reference values for spirometry in Brazilian children [PDF]
Jornal Brasileiro de PneumologiaObjective: To generate reference values for spirometry in Brazilian children 3-12 years of age and to compare those values with the values employed in the equations currently in use in Brazil. Methods: This study involved healthy children, 3-12 years of
Marcus Herbert Jones +14 more
doaj +3 more sources
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Reference values for methacholine reactivity (SAPALDIA study)
Respiratory Research, 2005 Background The distribution of airway responsiveness in a general population of non-smokers without respiratory symptoms has not been established, limiting its use in clinical and epidemiological practice.
Perruchoud André +9 more
doaj +1 more source
Some Remarks on the Rideal-Walker Test and on the Rideal-Walker Method. With Special Reference to the “Life Factor” and To The “Mechanics of Disinfection” and their Influence on Velocity and Equilibrium Values [PDF]
, 1912 Samuel Rideal, Eric Keightley Rideal
openalex +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Spirometry reference values in the Brazilian population
Brazilian Journal of Medical and Biological ResearchThe aim of the present study was to provide new spirometry reference equations in a sample of the Brazilian population for the following parameters: forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC ratio, peak of ...
R. Rufino +6 more
doaj +1 more source
HEMATOLOGIC REFERENCE VALUES FOR HEALTHY ADULT SAUDIS
Hematology, Transfusion and Cell Therapy, 2021 Background: Laboratory hematological tests are widely used in clinical practice to assess health and disease conditions. Although, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the Clinical and Laboratory Standards
Salwa Bakr
doaj
Quantifying the impact of model inaccuracy in climate change impact assessment studies using an agro-hydrological model [PDF]
Numerical simulation models are frequently applied to assess the impact of climate change on hydrology and agriculture. A common hypothesis is that unavoidable model errors are reflected in the reference situation as well as in the climate change ...
Droogers, P. +2 more
core +1 more source