Results 101 to 110 of about 8,013 (292)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The semantic significance of Donnellan's referential/attributive distinction

open access: yes, 1997
grantor: University of TorontoIn "Reference and Definite Descriptions", Keith Donnellan introduces the notion of referential and attributive uses of definite descriptions--phrases such as "the author of Waverly".
Hunter, Andrew John
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

A study in referential coherence: Chinese writers of English

open access: yes, 2010
Chinese writers of English often have problems in making their text coherent. This study is aimed to find out the possible factors in weakening coherence in their English essays.
Li, H.,
core  

O Livro Azul sobre o solipsismo e os usos do ‘Eu’: Uma leitura dialética

open access: yesDoisPontos, 2012
This paper argues for a dialectical reading of Wittgenstein’s grammatical reminders concerning the uses of the first person pronoun in The Blue Book. Against a widespread, ‘non-referential’ view which takes those reminders as direct attempts
Jônadas Techio
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

A NUMERICAL STUDY OF WATER PROPAGATION AND BREAKING USING SPH METHOD [PDF]

open access: yesJournal of Engineering Science and Technology, 2017
A breaking wave is a violent natural event that involves highly complex phenomena, such as large deformation of free surface, turbulence, vortex generation, strong interaction between wave and structures, etc.
COELHO J. G.   +3 more
doaj  

Metaphorical Singular Reference. The Role of Enriched Composition in Reference Resolution

open access: yesThe Baltic International Yearbook of Cognition, Logic and Communication, 2008
It is widely accepted that, in the course of interpreting a metaphorical utterance, both literal and metaphorical interpretations of the utterance are available to the interpreter, although there may be disagreement about the order in which these ...
Anne Bezuidenhout
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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