Results 251 to 260 of about 112,532 (287)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

On the socio-cognitive coercion mechanism of the formation of mandarin construction "V+ta(he)+XP". [PDF]

Front Psychol
Zhang P.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mental Spaces Theory and Multilayered Meaning Construction. [PDF]

Wiley Interdiscip Rev Cogn Sci
Kwon I.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Epistemological Foundation for the Use of the Linguistic Measures of the Referential Process. [PDF]

J Psycholinguist Res
Negri A, Barazzetti A.
europepmc   +1 more source

Brain Abnormalities During Self-Referential Task in Subthreshold Depression: A Near-Infrared Spectroscopy Study. [PDF]

Cureus
Nakano W, Yokoyama S, Sato H.
europepmc   +1 more source

Research Insights on 'Problematic Use of Short Video': A Comprehensive Review Exploration in Psychological Context. [PDF]

Addict Biol
Li T, Liu H, Hu R, Liu X.
europepmc   +1 more source

Conspecific alarm calls, but not food-associated calls, elicit affect-based and object-based mental representations in a bonobo (<i>Pan paniscus</i>). [PDF]

R Soc Open Sci
Lahiff NJ, Clay Z, Epping AJ, Taglialatela JP, Townsend SW, Slocombe KE.   +5 more
europepmc   +1 more source

Attenuated conflict self-referential information facilitating conflict resolution. [PDF]

NPJ Sci Learn
Li Z, Wang J, Chen Y, Li Q, Yin S, Chen A.   +5 more
europepmc   +1 more source