Results 151 to 160 of about 2,877,856 (360)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Understanding delays in chronic limb‐threatening ischaemia care: Application of the theoretical domains framework to identify factors affecting primary care clinicians' referral behaviours

Journal of Foot and Ankle Research
Introduction Patients in the community with suspected Chronic limb‐threatening ischaemia (CLTI) should be urgently referred to vascular services for investigation and management. The Theoretical Domains Framework (TDF) allows identification of influences
Eleanor Atkins, Panagiota Birmpili, Ian Kellar, Amundeep S. Johal, Qiuju Li, Sam Waton, Jonathan R. Boyle, Arun D. Pherwani, Ian Chetter, David A. Cromwell   +9 more
doaj   +1 more source

Cardiac Rehabilitation in Patients with Coronary Heart Disease – Provision, Attendance, and Outcomes: Results from the INTERASPIRE Survey from Fourteen Countries Across Six WHO Regions

Global Heart
Background: INTERASPIRE was an observational study of patients with coronary heart disease (CHD) from 88 hospitals in 14 countries across all six WHO regions.
Kornelia Kotseva, Dirk De Bacquer, Catriona Jennings, John William McEvoy, Lars Ryden, Kausik K. Ray, Gregory Y. H. Lip, Iris Erlund, Sandra Ganly, Terhi Vihervaara, Agnieszka Adamska, Ana Abreu, Wael Almahmeed, Ade Meidian Ambari, Susan Connolly, Junbo Ge, Irene Gibson, Hosam Hasan-Ali, Sue Hennessy, Yong Huo, Piotr Jankowski, Rodney M. Jimenez, Jennifer Jones, Yong Li, Ahmad Syadi Mahmood Zuhdi, Abel Makubi, Amam Chinyere Mbakwem, Lilian Mbau, Jose Luis Navarro Estrada, Okechukwu Samuel Ogah, Elijah Nyainda Ogola, Adalberto Quintero–Baiz, Mahmoud Umar Sani, Maria Ines Sosa Liprandi, Jack Wei Chieh Tan, David R Thompson, Miguel Alberto Urina Triana, Tee Joo Yeo, David Wood, Guy G. De Backer, on behalf of the INTERASPIRE Investigators   +40 more
doaj   +1 more source

Inappropriate referrals [PDF]

British Dental Journal, 2020
H, Bradley, O, Barratt, M L, Simms, P A, Atkin   +3 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Other title: Nursing Facility Preadmission Assessment and Referral Program educational bulletins.

, 1994
Title from caption.; "Kansas Department of Social and Rehabilitation Services (SRS) and Bock Associates based on recommendations of the Nursing Facility Preadmission Assessment and Referral program Continuous Quality Improvement (CQI) team prepared the ...
Kansas. Department of Social and Rehabilitation Services.
core  

Development and internal validation of a nomogram for predicting referral or hospitalization risk in children with community-acquired influenza

Frontiers in Pediatrics
BackgroundTo develop and internally validate a nomogram for predicting referral or hospitalization risk in children with community-acquired influenza based on clinical indicators, thereby providing primary healthcare institutions with evidence-based ...
Xiaoman Cai, Jiabin Yang, Shiyou Luo, Mufan Chen, Yaoting Su, Ailing Zhang, Bin Wang, Xueying Meng   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Letter of Consequence: Referral Letters from General Practitioners to Secondary Mental Health Services [PDF]

The referral letter is a key instrument in moving patients from primary to secondary care services. Consequently, the circumstances in which a referral should be made and its contents have been the subject of clinical guidelines. This article is based on
Shaw, Ian, Clegg Smith, Katherine M, Middleton, Hugh, Woodward, Louise   +3 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source