Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Emergency Department: Effectiveness of a Referral Intervention for High Utilizers
This research examined the impact of a referral intervention for patients with high utilization of the Emergency Department (ED) for non-‐emergent care.
Kang-Lim, Tina Jee Yung
core
Evaluation of Infants with Neonatal Cholestasis: Experience of a Tertiary Referral Center in Turkey [PDF]
Dilek Gürlek Gökçebay +3 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
SHIELD: An AI Framework for Skeletal Health Intelligence and Early Lesion Detection to Improve Orthopedic Referrals. [PDF]
Alili A +4 more
europepmc +1 more source
Antiepileptic Drug Adherence and Associated Factors Among Adult Epileptic Patients Attending Neurology Referral Clinic in Adama Hospital Medical College, Ethiopia [PDF]
Tadesse Seda
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Healthcare Access Through Digital Coordination: A Nationwide Analysis of Obstetrics and Gynecology E-Referral Patterns in Saudi Arabia. [PDF]
Alharbi AA +11 more
europepmc +1 more source

