Results 91 to 100 of about 728 (254)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Interpolatory refinable functions, subdivision and wavelets [PDF]

open access: yes, 2005
Thesis (DSc (Mathematical Sciences))--University of Stellenbosch, 2005.Subdivision is an important iterative technique for the efficient generation of curves and surfaces in geometric modelling.
Hunter, Karin M.
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

REFINABLE STEP FUNCTION ON LOCAL FIELDS OF POSITIVE CHARACTERISTIC AND ALGORITHM FOR CONSTRUCTING SUCH FUNCTION [PDF]

open access: yes, 2017
В работе приводится алгоритм построения ступенчатой масштабирующей функции с компактным носителем на локальных полях положительной характеристики.The algorithm for constructing compactly supported refinable step function on local fields of positive ...
Крусс Юлия Сергеевна
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Symmetric Multivariate Orthogonal Refinable Functions

open access: yes, 2003
In this paper, we shall investigate the symmetry property of a multivariate orthogonal M-refinable function with a general dilation matrix M . For an orthogonal M-refinable function # such that # is symmetric about a point (centro-symmetric) and ...
Bin Han
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Symmetric multivariate orthogonal refinable functions

open access: yes, 2008
. In this paper, we shall investigate the symmetry property of a multivariate orthogonal M-refinable function with a general dilation matrix M. For an orthogonal M-refinable function φ such that φ is symmetric about a point (centro-symmetric) and φ ...
Bin Han
core  

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