Results 61 to 70 of about 728 (254)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Multiwavelet Frames from Refinable Function Vectors
, 2001 Starting from any two compactly supported d-refinable function vectors in L 2 (R) multiplicity r and dilation factor d, we show that it is always possible to construct 2rd wavelet functions with compact support such that they generate a pair of dual d ...
Qun Mo, Bin Han
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Multiwavelet frames from refinable function vectors
, 2008 Starting from any two compactly supported d-refinable function vectors in L2(R) r with multiplicity r and dilation factor d, we show that it is always possible to construct 2rd wavelet functions with compact support such that they generate a pair of
Qun Mo, Bin Han
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
EXAMPLES OF REFINABLE COMPONENTWISE POLYNOMIALS
, 2007 . This short note presents four examples of compactly supported symmetric refinable componentwise polynomial functions: (i) a componentwise constant interpolatory continuous refinable function and its derived symmetric tight wavelet frame; (ii) a ...
Bi, N. +8 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Computing the smoothness exponent of a symmetric multivariate refinable function
, 2001 . Smoothness and symmetry are two important properties of a refinable function. It is known that the Sobolev smoothness exponent of a refinable function can be estimated by computing the spectral radius of a certain finite matrix which is generated from ...
Bin Han, Han, Bin
core
Classification of Refinable Splines in ℝ d
, 2010 A refinable spline in ℝd is a compactly supported refinable function whose support can be decomposed into simplices such that the function is a polynomial on each simplex. The best-known refinable splines in ℝd are the box splines. Refinable splines play
Wang, Yang +3 more
core +1 more source