Results 101 to 110 of about 157,821 (303)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Bending and free vibration analysis of thick isotropic plates by using exponential shear deformation theory

Applied and Computational Mechanics, 2012
This paper presents a variationally consistent an exponential shear deformation theory for the bi-directional bending and free vibration analysis of thick plates. The theory presented herein is built upon the classical plate theory.
Sayyad A. S., Ghugal Y. M.
doaj  

Multilayered plate elements with node-dependent kinematics for electro-mechanical problems

International Journal of Smart and Nano Materials, 2018
In the present work, a new class of finite elements (FEs) for the analysis of composite and sandwich plates embedding piezoelectric skins and patches is proposed.
E. Carrera, S. Valvano, G. M Kulikov
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

MULTILAYERED PLATE ELEMENTS WITH NODE-DEPENDENT KINEMATICS FOR THE ANALYSIS OF COMPOSITE AND SANDWICH STRUCTURES

Facta Universitatis. Series: Mechanical Engineering, 2017
In this paper a new plate finite element (FE) for the analysis of composite and sandwich plates is proposed. By making use of the node-variable plate theory assumptions, the new finite element allows for a simultaneous analysis of different subregions of
Stefano Valvano, Erasmo Carrera
doaj   +1 more source

Nanoscale clusters in the high performance thermoelectric AgPbmSbTem+2

, 2005
The local structure of the AgPbmSbTem+2 series of thermoelectric materials has been studied using the atomic pair distribution function (PDF) method. Three candidate-models were attempted for the structure of this class of materials using either a one ...
E. S. Božin, Eric Quarez, H. Lin, M. G. Kanatzidis, S. J. L. Billinge, S. J. L. Billinge, S. J. L. Billinge, T. Egami   +7 more
core   +1 more source

Bending and Free Vibration Analysis of Isotropic Plate Using Refined Plate Theory [PDF]

Bonfring International Journal of Industrial Engineering and Management Science, 2013
In this paper, Trigonometric shear deformation theory is applied for bending and free vibration analysis of thick plate. In this theory in plane displacement field uses sinusoidal function in terms of thickness coordinate. It accounts for realistic variation of the transverse shear stress through the thickness and satisfies the shear stress free ...
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Multi-scale Refined Zigzag Theory for Multilayered Composite and Sandwich Plates with Improved Transverse Shear Stresses [PDF]

, 2013
The Refined Zigzag Theory (RZT) enables accurate predictions of the in-plane displacements, strains, and stresses. The transverse shear stresses obtained from constitutive equations are layer-wise constant.
Di Sciuva, Marco, Gherlone, Marco, Iurlaro, Luigi, Tessler, Alexander   +3 more
core   +1 more source