Results 81 to 90 of about 6,238,485 (295)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Vibration Analysis of Laminated Composite Plates Carrying Rotating Circular Mass [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2014
In this paper, the free vibration response of a laminated composite rectangularplate supporting a rotating circular patch mass is studied. The two variable refined platetheory that employs only two unknown functions as against three in the case of ...
Reza Alibakhshi, Reza Akbari Alashti
doaj  

Free vibration of a micro-scale composite laminated Reddy plate using a finite element method based on the new modified couple stress theory

Results in Physics, 2020
In this study, a non-confirming element which is a combination of the BCIZ and refined triangular non-conforming element is developed for the free vibration analysis of micro-scale angle-ply laminated Reddy plate based on the new modified couple stress ...
Yunlong Ma, Yihang Gao, Wanli Yang, Dan He   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Modified Bolle - Reissner Theory of Plates Including Transverse Shear Deformations

Latin American Journal of Solids and Structures
In this work, new equations for first-order shear deformation plates are deduced taking into account the kinematic assumptions of the Bolle-Reissner theory but considering the equilibrium equations in the deformed configuration for the plate.
J. M. Martínez Valle, P. Martínez-Jiménez   +1 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A quasi-3D theory for vibration and buckling of functionally graded sandwich beams [PDF]

, 2015
This paper presents a finite element model for free vibration and buckling analyses of functionally graded (FG) sandwich beams by using a quasi-3D theory in which both shear deformation and thickness stretching effects are included.
Thai, Huu-Tai, Inam, Fawad, Lee, Jaehong, Vo, Thuc, Nguyen, Trung-Kien   +4 more
core   +1 more source

Flexure of thick orthotropic plates by exponential shear deformation theory

Latin American Journal of Solids and Structures
In the present paper, a variationally consistent exponential shear deformation theory taking into account transverse shear deformation effect is presented for the flexural analysis of thick orthotropic plates.
A. S. Sayyad
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source