Results 71 to 80 of about 6,238,485 (295)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Vibration suppression of advanced plates embedded magnetostrictive layers via various theories
Journal of Materials Research and Technology, 2020 Vibration suppression analysis of a laminated composite plate embedded magnetostrictive layers is presented with/without the transverse shear and normal strains effects are taken into account in this study.
Ashraf M. Zenkour, Hela D. El-Shahrany
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bending solution of high-order refined shear deformation-theory for rectangular composite plates
, 1994 A new high-order refined shear deformation theory based on Reissner's mixed variational principle in conjunction with the state- space concept is used to determine the deflections and stresses for rectangular cross-ply composite plates.
LIU, P (reprint author), NORTHWESTERN POLYTECH UNIV,DEPT AIRCRAFT,XIAN 710072,PEOPLES R CHINA. +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Latin American Journal of Solids and StructuresA numerical method is developed for the buckling analysis of moderately thick plate with different boundary conditions. The procedure use the finite strip method in conjunction with the refined plate theory (RPT).
Saeed Mirzaei +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The Reissnerian algorithms in the refined theories of the bending of plates [PDF]
Applications of Mathematics, 1968 Starting from the refined theories of the bending of plates proposed by I. Babuska and M. Prager and using the variational principle a differential equation of infinite order is derived for the special case of one unknown function $w_0(x,y)$. By the introduction of polymoments and poly-shear forces it is shown that the obtained boundary conditions ...
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source