Results 91 to 100 of about 6,238,485 (295)

Triangular Layered Finite Element Method for Reinforced Concrete Slabs

Structural Mechanics of Engineering Constructions and Buildings
This study presents an advanced layered triangular finite element method for modeling reinforced concrete (RC) slabs, incorporating material nonlinearity based on a refined global-local plate theory.
Dara A. Mawlood, Alexandr A. Koyankin
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Identification of Magnetorheological Layer Properties by Using Refined Plate Theory

, 2021
In this paper, the dynamic characteristics of sandwich plates with external rigid layers and an upper layer with magnetorheological properties (MR) are investigated.
Lyubomyr Sopilnyk, Orest Horbay, Eugeniusz Koda, Ivan Kernytskyy, Ruslan Humenuyk, Yaroslav Sholudko, Bohdan Diveyev, Piotr Osinski   +7 more
core   +1 more source

Bending and free vibration analysis of thick isotropic plates by using exponential shear deformation theory

Applied and Computational Mechanics, 2012
This paper presents a variationally consistent an exponential shear deformation theory for the bi-directional bending and free vibration analysis of thick plates. The theory presented herein is built upon the classical plate theory.
Sayyad A. S., Ghugal Y. M.
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Refined 9-Dof triangular Mindlin plate elements

, 2001
Based on the Mindlin/Reissner plate theory, two refined triangular thin/thick plate elements, the conforming displacement element DKTM with one point quadrature for the part of shear strain and the element RDKTM with the re-constitution of the shear ...
Wanji, C, Cheung, YK
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Multilayered plate elements with node-dependent kinematics for electro-mechanical problems

International Journal of Smart and Nano Materials, 2018
In the present work, a new class of finite elements (FEs) for the analysis of composite and sandwich plates embedding piezoelectric skins and patches is proposed.
E. Carrera, S. Valvano, G. M Kulikov
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source