Results 101 to 110 of about 6,238,485 (295)

Refined quadrilateral element based on Mindlin/Reissner plate theory

, 2000
A new quadrilateral thin/thick plate element RDKQM based on the Mindlin/Reissner plate theory is proposed. The exact displacement function of the Timoshenko's beam is used to derive the element displacements of the refined element RDKQM.
Wanji, C, Cheung, YK
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Nonlocal Harmonically Varying Heat in a Magneto-Thermoelastic Thick Plate Using Simple and Refined Lord and Shulman Theories

Mathematics
This work presents a solution to the nonlocal harmonically varying heat model in a magneto-thermoelastic thick plate. The classical, simple, and refined Lord and Shulman theories of thermoelasticity are applied.
Ashraf M. Zenkour, Maryam H. Aljadani
doaj   +1 more source

A Refined theory of generally laminated plates

, 1982
Bibliography: p. 143-146.
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Problemas de contato unilateral em placas semi-espessas, sujeitas a grandes deflexões, utilizando uma teoria de ordem superior [PDF]

, 1996
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoNeste trabalho é apresentada uma formulação incremental de elementos finitos para problemas de contato em placas, submetidas a grandes deslocamentos e com restrições ...
Barp, Jackson Luis
core  

Finite element model based on refined plate theories for laminated glass units

Latin American Journal of Solids and Structures
Laminated glass units exhibit complex response as a result of different mechanical behavior and properties of glass and polymer foil. We aim to develop a finite element model for elastic laminated glass plates based on the refined plate theory by Mau ...
Alena Zemanová, Jan Zeman, Michal Šejnoha   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source