Results 61 to 70 of about 10,403 (265)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Vibration Analysis of Laminated Composite Plates Carrying Rotating Circular Mass [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2014 In this paper, the free vibration response of a laminated composite rectangularplate supporting a rotating circular patch mass is studied. The two variable refined platetheory that employs only two unknown functions as against three in the case of ...
Reza Alibakhshi, Reza Akbari Alashti
doaj
Results in Physics, 2020 In this study, a non-confirming element which is a combination of the BCIZ and refined triangular non-conforming element is developed for the free vibration analysis of micro-scale angle-ply laminated Reddy plate based on the new modified couple stress ...
Yunlong Ma +3 more
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The Reissnerian algorithms in the refined theories of the bending of plates [PDF]
Applications of Mathematics, 1968 Starting from the refined theories of the bending of plates proposed by I. Babuska and M. Prager and using the variational principle a differential equation of infinite order is derived for the special case of one unknown function $w_0(x,y)$. By the introduction of polymoments and poly-shear forces it is shown that the obtained boundary conditions ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Modified Bolle - Reissner Theory of Plates Including Transverse Shear Deformations
Latin American Journal of Solids and StructuresIn this work, new equations for first-order shear deformation plates are deduced taking into account the kinematic assumptions of the Bolle-Reissner theory but considering the equilibrium equations in the deformed configuration for the plate.
J. M. Martínez Valle +1 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Flexure of thick orthotropic plates by exponential shear deformation theory
Latin American Journal of Solids and StructuresIn the present paper, a variationally consistent exponential shear deformation theory taking into account transverse shear deformation effect is presented for the flexural analysis of thick orthotropic plates.
A. S. Sayyad
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A Refined theory of generally laminated plates
, 1982 Bibliography: p. 143-146.
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