Results 41 to 50 of about 10,403 (265)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Analysis of the mechanical behavior of functional gradient porous plates on an elastic foundation

Scientific African
Summary: This study presents an in-depth analysis of the bending behavior of porous functionally graded material (P-FGM) plates resting on a Winkler–Pasternak elastic foundation. Two types of transverse loading are considered: uniform and sinusoidal. The
Karim Fikri, Khalid Adnaoui, Laila Mouakkir   +2 more
doaj   +1 more source

Static and dynamic behaviors of laminated composite plates resting on elastic foundation

Journal of Building Materials and Structures, 2022
This present study consists to analyze the mechanical buckling and the free vibration stabilities of antisymmetric cross-ply and angle-ply laminated composite plates using a refined high order shear deformation theory of four variables against five in ...
Tahir Ghazoul , Mohamed Atif Benatta , Mohamed Bachir Bouiadjra   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Refined theory for linearly elastic plates: Laminae and laminates [PDF]

Mathematics and Mechanics of Solids, 2011
It is well known that bending and stretching modes of deformation in linearly-elastic plates decouple at leading order in thickness provided that the mid-plane is a plane of reflection symmetry of the three-dimensional material properties. This situation being the exception rather than the norm, it is important to have a model that accommodates ...
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Buckling analysis of thick plates using refined trigonometric shear deformation theory

Journal of Materials and Engineering Structures, 2015
In this paper, a refined trigonometric shear deformation plate theory is applied for the buckling analysis of thick isotropic square and rectangular plates.
Sachin Madhavrao Gunjal, Rajesh Baburao Hajare, Atteshamuddin Shamshuddin Sayyad, Manas Dipak Ghodle   +3 more
doaj  

Bending of functionally graded plates via a refined quasi-3D shear and normal deformation theory

Curved and Layered Structures, 2018
Bending of functionally graded plate with two reverse simply supported edges is studied based upon a refined quasi three-dimensional (quasi-3D) shear and normal deformation theory using a third-order shape function.
Zenkour Asharf M., Alghanmi Rabab A.
doaj   +1 more source

Evaluation of the Best New Cross-ply Laminated Plate Theories through the Axiomatic/Asymptotic Approach [PDF]

Journal of Applied and Computational Mechanics, 2018
This paper presents Best Theory Diagrams (BTDs) constructed from various non-polynomial theories for the static analysis of thick and thin symmetric and asymmetric cross-ply laminated plates. The BTD is a curve that provides the minimum number of unknown
S. Candiotti, J.L. MANTARI
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source