Results 171 to 180 of about 5,714,792 (303)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Development and National Implementation of a Standardized Physiotherapy Assessment Package for Pediatric Asthma and Dysfunctional Breathing. [PDF]

Pediatr Pulmonol
Wells C, Hepworth C, Barker N.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Sepsis Diagnostic Excellence: Development and Validation of a Theoretical Framework for Conceptualizing Accurate, Timely Sepsis Diagnosis. [PDF]

Crit Care Explor
Birken SA, Shrestha S, Clark LS, Wagi CR, Reilly KL, Kowalkowski MA, Palakshappa JA, King JE, Miller CD, Sebok-Syer SS, Taylor SP.   +10 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Coupled Thermal and Nonlocal Effects in Advanced Composite Nanobeams: An Efficient Higher-Order Modeling Approach. [PDF]

Nanomaterials (Basel)
Alghanmi RA, Houari MSA.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

ValuesML: A new multilingual dataset for values detection in news and political manifestos. [PDF]

Behav Res Methods
Scharfbillig M, Reitis-Münstermann T, Stefanovitch N, Kiesel J, Brock PS, Sneddon J, Cartier E, Ardag M, Arieli S, Daniel E, Dobewall H, Karl J, Krasteva A, Oeschger TP, Petasis G, Russo L, Seddone A, Tamo-Larrieux A, van Herk H, Avcı N, Bobba G, Chiron P, Çoymak A, Dagioglou M, Katsamori D, Leijen I, Öney B, Scholz-Kuhn R, Zankina E, Astor S, Auer P, Aulino L, Bardi A, Battaglia F, Beierlein C, Benish-Weisman M, Christodoulou C, Collins PR, Coppola I, Dâmaso M, Morren M, Elizarov E, Erlich N, Ezeigwe-Ephraim P, Fischer R, Gaeta MC, Gatt L, Gerera N, Goldman S, Gonthier F, Habermann S, Hristova M, Yapali DI, Izzo L, Kapetanakis P, Kışlıoğlu R, Koleva C, Koleva R, Lake J, Mesplou M, Ninova V, Önal ES, Oppenheim-Weller S, Ozturk D, Paparrigopoulos IE, Ponizovskiy V, Reeskens T, Romano MF, Schalk T, Starovolsky-Shitrit A, Smallenbroek O, Topuz Ö, Vauclair CM, Di Vetta G, Ye S.   +74 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The role of receptive arts and culture to improve anxiety, depression and psychological distress in young people: a realist review. [PDF]

Front Child Adolesc Psychiatry
Hayes D, Wright J, Chandler L, Albaya de Gago K, Ng S, Langley J, Fancourt D, Bhui K, Mooney R, Syed Sheriff R.   +9 more
europepmc   +1 more source