Results 171 to 180 of about 553,328 (316)

Database-Guided Local Refinement and Truncated Power Estimation for LEO Uplink Anti-Interference Beamforming. [PDF]

Sensors (Basel)
Zhang J, Zhang X, Sheng T, Lv Z, Yuan C, Zhou Z, Chen P.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Synergistic Effects of Using Trace NbB₂ and Ti Additions to Refine the Microstructure and Enhance the Mechanical Properties of PDC Al-Si Alloy. [PDF]

Materials (Basel)
Fan W, Zhang Z, Zhang Z.
europepmc   +1 more source

Using UML-B and U2B for formal refinement of digital components

, 2003
In this paper we look at using formal methods to verify the transformation of a digital design from abstract functional specification to bit level implementation.
Snook, Colin, Sandstrom, Kim
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Refining MediQuit: an iterative, participatory approach to shared decision-making in deprescribing. [PDF]

Implement Sci Commun
Kornder N, Burkhardt S, Hierasimowicz K, Viniol A, Donner-Banzhoff N.   +4 more
europepmc   +1 more source

Grain refinement and nucleation processes in Aluminium alloys through liquid shearing

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The industrial practice of grain refinement of aluminium alloys involves the addition of inoculant particles to initiate alpha-aluminium grains at small ...
Haghayeghi, Reza
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Moving beyond oral gavage: micropipette-guided drug administration (MDA) as a 3R refinement for voluntary oral drug delivery in rodents. [PDF]

Lab Anim (NY)
Nilsson FAM, Krzyzaniak O, Dietrich M, Steiner S, Kämpfen L, Jirkof P, Meyer U, Johansen P.   +7 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source