Results 131 to 140 of about 55,415 (305)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Study on instability evolution mechanism of intermediate bridge retaining slope

International Journal of Coal Science & Technology
Excavation is one of the key factors inducing slope instability in open-pit mines, particularly for intermediate bridge-supported slopes subjected to dual excavation disturbances.
Dong Wang, Zuchao Liang, Guanghe Li, Zihuan Hu, Pengfei Cui, Jiankang Feng, Pengyu Wang, Kun Fang, Pengjiao Zhang   +8 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

On Decolonial Crackings and Sowings

The Thinker
The university is one place, among many others, to sow and nurture decolonial thought, analysis, reflection, and action; analytical-actional thought, and thoughtful-reflective actionings, inside, outside, despite—and that both spite and crack—the ...
Catherine E. Walsh
doaj   +1 more source

Language, listening and learning:critically reflective accountability for INGOs [PDF]

, 2013
Crack, Angela Maria
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Ionic soil stabilizers for mitigating drying shrinkage in solidified iron tailings: Enabling large-scale road base application

Case Studies in Construction Materials
In the utilization of silty iron tailings as a pavement base material, it is crucial to access the drying shrinkage of the pavement base to mitigate the risk of reflective cracking in the surface course.
Jian Jia, Meiling Xu, Jiang Zhu, Xiaolei Lu, Lina Zhang, Xin Cheng   +5 more
doaj   +1 more source

An overlay design method for reflective cracking

, 2000
The purpose of this paper is to develop a pavement design method to address reflective cracking using sound mechanistic principles reinforced by practical experience. This paper presents the initial concept of the proposed overlay design method. Test sections have been constructed to assess the effect of overlay thickness, crack width and load to ...
Pais, Jorge C., Sousa, Jorge B., Way, George B., Stubstad, Richard N.   +3 more
openaire   +1 more source