Results 111 to 120 of about 55,415 (305)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Green Up Pavement Rehabilitation Design Tool [PDF]

, 2019
While designers produce pavement rehabilitation recommendations every day, for projects of all sizes, most designers have little information on the environmental impact of their recommendations.
Andrei, Dragos, Kochan, Robert E., Perez, Jose H.   +2 more
core   +1 more source

Evaluation of the surface strength of glass plates shaped by hot slumping process

, 2014
The Hot Slumping Technology is under development by several research groups in the world for the realization of grazing-incidence segmented mirrors for X-ray astronomy, based on thin glass plates shaped over a mould at temperatures above the ...
Basso, S., Bavdaz, M., Borsa, F., Citterio, O., Civitani, M., D'Este, A., Dall'Igna, R., Ghigo, M., Martelli, F., Pareschi, G., Parodi, G., Proserpio, L., Salmaso, B., Silvestri, M., Sironi, G., Spiga, D., Tagliaferri, G., Wille, E.   +17 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The reflective cracking in thin surfacings

, 1998
This paper shows a laboratory study on reflection cracking in thin surfacings, where the reflective cracking take an important point in pavement life, undertaken with the Reflective Cracking Device and the Crack Activity Meter. The Crack Activity Meter was used to measure load associated differential vertical and horizontal movement between the two ...
Pais, Jorge C., Pereira, Paulo A. A., Azevedo, M. C. M., Sousa, Jorge B.   +3 more
openaire   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Fracture characteristics of asphalt mixtures containing asphalt millings with geosynthetic fragments [PDF]

E3S Web of Conferences
The increasing cost of asphalt and environmental concerns have created a greater interest in exploring the possibility of incorporating higher percentages of reclaimed asphalt pavement (RAP) materials in asphalt mixtures.
Saxena Ashray, Kumar V. Vinay, Zornberg Jorge G.   +2 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Numerical investigation of pre-flawed FGM tubes repaired with different composite jackets under sequential gaseous detonation loading

Results in Engineering
Investigation on the structural response of pre-flawed functionally graded material (FGM) cylindrical tubes submitted to sequential detonation loading is the main contribution of this study. Analyses are made for repaired and unrepaired tubes using three
Mohammad Malekan, Carlos A. Cimini, Jr.
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source