Results 91 to 100 of about 55,415 (305)

Observation of Damage Growth in Compressively Loaded Laminates [PDF]

, 1983
An experimental program to determine tie phenomenological aspects of composite-panel failure under simultaneous compressive n-plane loading and low-velocity transverse impact [C-75 m/s (0-250 ft/s)] is described.
Babcock, C. D., Chai, H., Knauss, W. G.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Asphalt rubber interlayer benefits on reflective crack retardation of flexible pavement overlays [PDF]

, 2011
This paper provides an overview of the asphalt rubber interlayer benefits on reflective crack retardation in flexible pavement preservation and rehabilitation strategies.
Minhoto, Manuel J. C., Pais, Jorge C., Shatnawi, Shakir   +2 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Evaluation of anti-reflective crack resistance based on the UFAC stress-absorbing layer

河南理工大学学报. 自然科学版
ObjectivesTo address the issue of reflective cracking in “white and black” pavement technology， this paper proposes an optimized design for a skeleton-dense UFAC stress-absorbing layer.
LI Zhi, TONG Jing
doaj   +1 more source

Fatigue performance of geosynthetic-reinforced asphalt using DIC [PDF]

E3S Web of Conferences
The main objective of this study is to evaluate the influence of geosynthetic reinforcement on the fatigue performance of asphalt overlays using double-layered specimens extracted from experimental sections.
Correia Natalia S., Souza Ana Laura C., Dos Santos Karolina M., Kumar V. Vinay   +3 more
doaj   +1 more source

A specified procedure for distress identification and assessment for urban road surfaces based on PCI [PDF]

, 2017
In this paper, a simplified procedure for the assessment of pavement structural integrity and the level of service for urban road surfaces is presented.
Loprencipe, Giuseppe, PANTUSO ROMERO, Antonio   +1 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Performance Evaluation of Geocomposite Reinforcement in Flexible Pavements using Marshall Test Protocol

MATEC Web of Conferences, 2018
Asphalt concrete pavements are prone to cracking due to external loads and extreme weathering conditions. Generally the failed asphalt concrete is over laid with new asphalt concrete surface to improve the riding surface; however after sometime the crack
Qadir Adnan, Choudhary Karam-un-Nisa
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source