Results 101 to 110 of about 55,415 (305)
The teacher as action researcher : Using technology to capture pedagogic form [PDF]
, 2008 The paper argues that we make best use of learning technologies if we begin with an understanding of educational problems, and use this analysis to target the solutions we should be demanding from technology.
Laurillard, Diana
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
BuildingsThis study investigated the impact of reflective cracking on the fatigue performance of asphalt pavements after milling and resurfacing under various conditions.
Hongfu Liu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Determining the relationship between rock colour and the type of physical weathering on desert pavements in arid landscapes, Ras Al Khaimah, UAE [PDF]
, 2008 Despite opposition to the theory that diurnal heat fluxes within desert rocks cause enough internal stress to form cracks on clasts leading to the break down of the desert material, this study provides further evidence that this is a credible process in ...
O.J.H. Swift
core
PP-wave reflection coefficient for vertically cracked media: Single set of aligned cracks
Journal of Applied Geophysics, 2023 The main goal of this paper is to analyse the influence of cracks on the azimuthal variations of amplitude. We restrict our investigation to a single set of vertical, circular, and flat cavities aligned along a horizontal axis. Such cracks are embedded in either isotropic surroundings or transversely isotropic background with a vertical symmetry axis ...
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Research on Fatigue Damage and Crack Propagation of Pre-Cut Seam Asphalt Mixture Composite Beams
Zhongwai GongluThis study investigated the influence of reflective cracking on the fatigue performance of asphalt pavements subjected to milling and resurfacing under varying service conditions.
HUANG Dengke, LIU Hongfu
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Yantu gongcheng xuebaoThe liner of underground gas storage cavern is used to transfer the internal pressure to the surrounding rock, and at the same time serves as the base of flexible sealing layer.
JIANG Zhongming 1, 2, GAN Lu 1, ZHANG Dengxiang 1, 3, XIAO Zhezheng 1, LIAO Junhui 1
doaj +1 more source