Results 71 to 80 of about 2,704 (260)

Performance Evaluation of Geocomposite Reinforcement in Flexible Pavements using Marshall Test Protocol

MATEC Web of Conferences, 2018
Asphalt concrete pavements are prone to cracking due to external loads and extreme weathering conditions. Generally the failed asphalt concrete is over laid with new asphalt concrete surface to improve the riding surface; however after sometime the crack
Qadir Adnan, Choudhary Karam-un-Nisa
doaj   +1 more source

Fatigue performance of geosynthetic-reinforced asphalt using DIC [PDF]

E3S Web of Conferences
The main objective of this study is to evaluate the influence of geosynthetic reinforcement on the fatigue performance of asphalt overlays using double-layered specimens extracted from experimental sections.
Correia Natalia S., Souza Ana Laura C., Dos Santos Karolina M., Kumar V. Vinay   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Fatigue Life of Pre-Cut Seam Asphalt Mixture Composite Beams: A Combined Study of Fatigue Damage Evolution and Reflective Cracking Extension

Buildings
This study investigated the impact of reflective cracking on the fatigue performance of asphalt pavements after milling and resurfacing under various conditions.
Hongfu Liu, Hong Lu, Xun Zhu, Zhengwei Yi, Xin Yu, Dongzhao Jin, Xinghai Peng, Songtao Lv   +7 more
doaj   +1 more source

Reflective Cracking Study: Summary Report [PDF]

, 2008
This report summarizes a series of eight first-level Heavy Vehicle Simulator testing reports, two laboratory reports on shear and fatigue testing, a forensic investigation report, a report on the backcalculation of deflection measurements, and a second-level analysis report, all of which document an investigation undertaken to validate Caltrans overlay
Jones, David, Harvey, John T, Monismith, Carl L.   +2 more
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Specular Reflection by Contacting Crack Faces

, 1984
Non-linear relations are postulated between the transmitted tractions and the crack opening displacements across contacting rough crack faces. For the opening mode these relations take into account that a crack easily opens, but that the resistance to crack closure increases rapidly as the rough crack faces come in contact.
Achenbach, J., Norris, A.
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research on Fatigue Damage and Crack Propagation of Pre-Cut Seam Asphalt Mixture Composite Beams

Zhongwai Gonglu
This study investigated the influence of reflective cracking on the fatigue performance of asphalt pavements subjected to milling and resurfacing under varying service conditions.
HUANG Dengke, LIU Hongfu
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source