Results 41 to 50 of about 138,992 (294)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Impact of bulk density assignment of bone on MRI‐based abdominal region radiotherapy planning for MR‐linac workflow

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The purpose of the present study was to evaluate the impact of bone relative electron density (rED) assignment on radiotherapy planning for the abdominal region. Methods Twenty patients who received abdominal radiotherapy using MR‐Linac and underwent magnetic resonance imaging (MRI) and computed tomography (CT) simulation were analyzed.
Kota Abe   +4 more
wiley   +1 more source

Attenuation of seismic refraction waves in sedimentary layers [PDF]

open access: yesKirkuk Journal of Science, 2008
A study of attenuation of seismic refraction waves in sedimentary layers is carried out at two sites near Al-Riyadh and Baiji towns, Kirkuk Governorate in order to determine the attenuation coefficients of the two sites.
Abboud S.Ishag   +2 more
doaj   +1 more source

A comparative study of knotless versus knotted transscleral suture-fixated intraocular lens implantation

open access: yesIndian Journal of Ophthalmology, 2022
Purpose: To compare functional outcomes and complication rates of two scleral fixated intraocular lens implantation (SFIOL) techniques. Methods: In this retrospective study, there were 30 eyes of 30 patients who underwent SFIOL implantation for ...
Sami Yilmaz   +2 more
doaj   +1 more source

Single View Refractive Index Tomography with Neural Fields [PDF]

open access: yesarXiv, 2023
Refractive Index Tomography is the inverse problem of reconstructing the continuously-varying 3D refractive index in a scene using 2D projected image measurements. Although a purely refractive field is not directly visible, it bends light rays as they travel through space, thus providing a signal for reconstruction. The effects of such fields appear in
arxiv  

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

open access: yesAdvanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim   +3 more
wiley   +1 more source

A method for creating materials with a desired refraction coefficient [PDF]

open access: yes, 2009
It is proposed to create materials with a desired refraction coefficient in a bounded domain $D\subset \R^3$ by embedding many small balls with constant refraction coefficients into a given material. The number of small balls per unit volume around every point $x\in D$, i.e., their density distribution, is calculated, as well as the constant refraction
arxiv   +1 more source

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer‐Lipid Hybrid Vesicles

open access: yesAdvanced Biology, EarlyView.
The successful in situ polymerization of microtubules in giant polymer‐lipid hybrid vesicles is illustrated. The microtubules formed in the giant hybrid vesicles exhibit different morphologies including lumenal network formation and membrane association. Abstract Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a
Paula De Dios Andres   +4 more
wiley   +1 more source

Retroreflector Approximation of a Generalized Eaton Lens [PDF]

open access: yes, 2011
We extended a previous study of the Eaton lens at specific refraction angles to the Eaton lens at any refraction angle. The refractive index of the Eaton lens is complicated and has not analytical form except at a few specific angles. We derived a more accessible form of the refractive index for any refraction angle with some accuracy by ...
arxiv   +1 more source

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