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Chronic Refractory Cough: A Case Study

Perspectives of the ASHA Special Interest Groups, 2017
This paper presents a successful behavioral case study in treatment of chronic refractory cough in a 60-year-old adult female. The efficacy for speech-language pathology treating chronic cough is discussed along with description of treatment regime. Discussion focuses on therapy approaches used and the patient's report of changes in quality of life and
Anna Maria Siciliano
openaire   +2 more sources

Structural and Functional Correlates of Higher Cortical Brain Regions in Chronic Refractory Cough

Chest, 2022
Background: Chronic refractory cough significantly impairs the psychological and social aspects of quality of life. Loss of inhibitory control is suggested as a potential central neurobiological mechanism underlying chronic refractory cough.
Jin An, You Sook Cho, Yong Hwan Kim
exaly   +2 more sources

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Productive Cough, a Forgotten Phenotype of Refractory Chronic Cough

Monitoring airway disease, 2021
Refractory chronic cough (RCC) patients typically complain of a dry cough. Sputum production in these patients has rarely been described in the literature. However, sputum production in RCC may be common, troublesome and particularly challenging to manage.We aimed to characterise patients referred to our regional specialist cough clinic who have ...
Jenny King, James Wingfield Digby, Sarah Hennessey, Paul Marsden, Jaclyn Smith   +4 more
openaire   +3 more sources

Management of chronic refractory cough

BMJ, 2015
Chronic refractory cough (CRC) is defined as a cough that persists despite guideline based treatment. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a substantial impact on quality of life and healthcare utilization. Several terms have been used to describe this condition, including the recently introduced term cough
Gibson, Peter G., Vertigan, Anne E.
openaire   +2 more sources

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials

Lancet, The, 2022
Background: Gefapixant is an oral P2X3 receptor antagonist that has previously shown efficacy and safety in refractory chronic cough and unexplained chronic cough.
Jaclyn Smith, Ian Pavord, Alyn Morice
exaly   +2 more sources

Treatment of Chronic, Refractory Cough with Baclofen

Respiration, 1998
Chronic, nonproductive cough may result from enhanced sensitivity of the cough reflex. Often, this debilitating symptom is refractory to standard antitussive therapy. Baclofen, an agonist of γ-aminobutyric acid (GABA), has been shown, in animals, to have antitussive activity via a central mechanism.
P V, Dicpinigaitis, K, Rauf
openaire   +2 more sources

The Efficacy of Bradanicline in Refractory Chronic Cough

Airway pharmacology and treatment, 2020
Background: Several clinical studies have implicated nicotine in reducing cough reflex sensitivity in both healthy smoking and non-smoking subjects. Bradanicline, a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist, may therefore be effective for refractory chronic cough (RCC), possibly through sensory gating in the central nervous ...
Yoshihiro Kanemitsu, Jaclyn Smith, Peter Butera, Brendan Canning, Peter Dicpinigaitis, Vivek Iyer, Michael Kitt   +6 more
openaire   +1 more source

Patient-Reported Qualitative Analysis of Chronic Refractory Cough

American Journal of Speech-Language Pathology, 2022
Purpose: Chronic cough has been shown to be associated with adverse effects on quality of life. There is a paucity of research characterizing quality-of-life factors associated with chronic refractory cough (CRC), a cough persisting > 8 weeks despite evaluation and treatment of possible etiologies.
Miranda L. Wright, Robert Brinton Fujiki, Tadeas Lunga, Susan L. Thibeault   +3 more
openaire   +2 more sources

The Healthcare Resource Utilization of Patients with Refractory Chronic Cough Compared to Those with Non-Refractory Chronic Cough

Lung
Refractory chronic cough (RCC) significantly impairs patient quality of life and poses a major challenge in clinical management. However, little is known about the healthcare resource utilization (HRU) of patients with RCC.The goal of our study is to describe the HRU and associated costs of RCC patients and those with non-refractory chronic cough (non ...
Guilleminault, Laurent, Dupin, Clairelyne, Portel, Laurent, Zysman, Maeva, Flament, Thomas, Roux, Pauline, Costa, Nadège, Mounié, Michael   +7 more
openaire   +3 more sources

P5 Prevalence of refractory chronic cough in a tertiary cough clinic

It’s time to talk about cough and spit, 2018
Introduction and objectives In the past, some respiratory centres reported success rates of 98% when treating chronic cough based on identifying and treating underlying conditions such as asthma, nasal disease and gastro-oesophageal reflux. However, cases refractory to treatment of potential underlying causes are increasingly recognised, especially in
B Al-Sheklly, I Satia, H Badri, S Khalid, J Haines, AA Woodcock, JA Smith   +6 more
openaire   +1 more source