Results 51 to 60 of about 988,764 (283)

Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients

Neuropsychiatric Disease and Treatment, 2019
Aixia Zhang,1,2 Gaizhi Li,1 Chunxia Yang,1 Penghong Liu,2 Yanfang Wang,1 Lijun Kang,2 Yuchen Wang,2 Kerang Zhang11Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Shanxi ...
Zhang A, Li G, Yang C, Liu P, Wang Y, Kang L, Wang Y, Zhang K   +7 more
doaj  

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Prefrontal–bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression

Nature Communications
Therapeutic options for refractory depression are urgently needed. We conducted a deep brain stimulation (DBS) randomized controlled trial of the bed nucleus of the stria terminalis (BNST), an extended amygdala structure, and nucleus accumbens (NAc) in ...
Linbin Wang, Yingying Zhang, Yuhan Wang, Qiong Ding, Luling Dai, Kejia Hu, Kuanghao Ye, Xin lv, Xiaoxiao Zhang, Alekhya Mandali, Luis Manssuer, Saurabh Sonkusare, Yijie Zhao, Peng Huang, Xian Qiu, Yixin Pan, Yijie Lai, Dianyou Li, Wei Liu, Shikun Zhan, Bomin Sun, Valerie Voon   +21 more
doaj   +1 more source

Probability of major depression classification based on the SCID, CIDI, and MINI diagnostic interviews: A synthesis of three individual participant data meta-analyses [PDF]

, 2020
Introduction: Three previous individual participant data meta-analyses (IPDMAs) reported that, compared to the Structured Clinical Interview for the DSM (SCID), alternative reference standards, primarily the Composite International Diagnostic Interview ...
Ioannidis, John PA, Collaboration, DEPRESsion Screening Data (DEPRESSD), Figueiredo, Bárbara, Ioannidis, John P A, Thombs, Brett D., Ioannidis, John P. A., Thombs, Brett D, DEPRESsion Screening Data (DEPRESSD) Collaboration, Wu, Yin, Tendais, Iva Alexandra Barbosa, Benedetti, Andrea, Luigi Grassi, Levis, Brooke   +12 more
core   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Late-life depression and rehabilitation [PDF]

, 2020
Major depression has a prevalence of 6% among the elderly, reaching 15% when minor depression is included. In clinical practice of rehabilitation, we should aware the fact that 6 - 15% of the elderly are subjects of minor/major depression who sometimes ...
Takako MIZUNO, Masatoshi TAKEDA, Takao INOUE, Eiji TANIGUCHI, Kenji ISHIKAWA, Koichi SHIMANO, Junya ORUI, Shunsuke NAKAMATSU, Kumiko TERAYAMA, Fumie TAZAKI, Takeshi KAMISHIMA, Maki TAKEI, Morihiro OKADA, Seigo MINAMI   +13 more
core   +1 more source

Multi‐Modal Low‐Power Adaptive Braille Recognition System Based on Hf0.3Zr0.7O2 Memristor

Advanced Science, EarlyView.
A multimodal adaptive perception system based on HZO ferroelectric memristor realizes efficient Braille digit recognition via reservoir computing. It delivers high recognition accuracy with ultralow‑energy analog computation, offering a promising hardware solution for environment‑robust neuromorphic assistive devices for visually impaired users ...
Jikang Xu, Jiacheng Wang, Ziye Li, Weidong Sun, Jianlin Wang, Qiang Lu, Wenjing Liu, Xiaoyang Liu, Yan Sun, Xiaobing Yan   +9 more
wiley   +1 more source

Psychological profile of individuals presenting with chronic cough

ERJ Open Research, 2017
Chronic refractory cough (CRC) is a common problem in respiratory clinics. Adverse effects on quality of life are documented in the literature, but relatively little is known about the underlying psychological factors in this patient population. We aimed
Katrin Hulme, Vincent Deary, Sian Dogan, Sean M. Parker   +3 more
doaj   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source