Results 61 to 70 of about 988,764 (283)

Intraparenchymal hemorrhage after electroconvulsive therapy

Interdisciplinary Neurosurgery, 2017
A 46-year-old woman with a history of medically refractory depression experienced a tonic-clonic seizure shortly after electroconvulsive therapy for severe depression.
Elizabeth W.J. Carlson, Howard Weeks, William T. Couldwell, M. Yashar S. Kalani   +3 more
doaj   +1 more source

Psychostimulants in the Treatment of Depressive Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2015
Despite antidepressant therapy of appropriate trial duration and dose optimization, 50-60% of depressed patients have an adequate treatment response, whereas only 35-40% achieve remission.
Okan Ekinci, Asli Erkan Ekinci, Selahattin Bolek   +2 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Ketamine enhanced ECT in refractory recurrent depression.

European Psychiatry
Introduction Recurrent Depressive Disorder is a chronic condition that significantly impacts the quality of life. Despite various treatment options, some patients face severe and treatment-resistant relapses.
B. Arribas-Simon, P. Martinez.Gimeno, M. Calvo-Valcarcel, C. Alario-Ruiz, O. Martin-Santiago   +4 more
doaj   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Quality of life in adults with refractory epilepsy in Thailand: a multicenter upcountry nationwide study

BMC Public Health
Introduction Health related quality of life (HRQoL) has become a pivotal outcome parameter for epilepsy management. Few studies have described the variables that impact quality of life (QoL) in patients with refractory epilepsy in developing Asian ...
Kanitpong Phabphal, Nunthamon wonghirundecha, Tabtim Chongsuvivatwong, Atiwat Soontornpun, Pichai Rochanapithayakorn, Arkhom Arayawichanont, Thuspaween Wasiwat, Arpart Nakao, Alan Geater   +8 more
doaj   +1 more source

Stereotactic radiosurgery for treatment resistant depression: Systematic review

World Neurosurgery: X
Background: Depression is a global health concern that significantly impacts the quality of life of those affected. Approximately 30 % of cases are resistant to currently approved treatment methods.
Jordan Vanleuven, Yusuke S. Hori, Tag Alsir Osama, Paul M. Harary, Austin Lui, Amit R. Persad, Armine Tayag, Sara C. Emrich, Louisa Ustrzynski, David Purger, David J. Park, Steven D. Chang   +11 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source