Results 81 to 90 of about 988,764 (283)

Benzodiazepines use in primary care England: Prescribing patterns and adverse consequences

British Journal of Clinical Pharmacology, EarlyView.
Aims Benzodiazepines (BZDs) are commonly prescribed for anxiety and insomnia but carry risks such as dependence, adverse drug reactions (ADRs) and mortality. Despite deprescribing efforts, the influence of recent prescribing trends, COVID‐19 and adverse outcomes on prescribing patterns in England remains uncertain.
Alvina Chaudhry, Muhammad Umair Khan, Barbara Conway, Syed Shahzad Hasan   +3 more
wiley   +1 more source

A systematic review of the effectiveness of docetaxel and mitoxantrone for the treatment of metastatic hormone-refractory prostate cancer [PDF]

, 2006
A systematic review was performed to evaluate the clinical effectiveness of docetaxel in combination with prednisolone (docetaxel is licensed in the UK for use in combination with prednisone or prednisolone for the treatment of patients with metastatic ...
Riemsma, R., Trowman, R., G Norman, E Fenwick, R Riemsma, Norman, G., Fenwick, E., Birtle, A., Collins, R., K Light, Light, K., A Birtle, Palmer, S., R Collins, S Palmer, R Trowman   +15 more
core   +1 more source

Exploring the early observations of parents supporting their children with school attendance problems (SAPs): A co‐produced study

British Educational Research Journal, EarlyView.
Abstract School Attendance Problems (SAPs) represent a significant challenge requiring early identification and intervention. Current service provision often does not recognise early indicators that parents observe, creating gaps between when initial concerns are raised and formal support is provided.
Tereza Aidonopoulou‐Read, Michelle Pyer, Beth Bodycote, Jackie Campbell, Kirsteen Pyer   +4 more
wiley   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source

Ketamine and Electroconvulsive Therapy for Treatment-Refractory Depression. [PDF]

Alpha Psychiatry, 2023
Huang XB, Zheng W.
europepmc   +1 more source

Percutaneous Transaxillary Access for Large‐Bore Cardiovascular Interventions: Evidence, Technique, and Complication Management

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Percutaneous transaxillary access is an established alternative to transfemoral large‐bore arterial access for transcatheter structural heart interventions and mechanical circulatory support (MCS). Although useful for overcoming hostile iliofemoral anatomy and providing prolonged support and patient mobilization in case of MCS, the axillary ...
Gioel Gabrio Secco, Marco Lombardi, Edoardo Elia, Juan Guido Chiabrando, Andrea Demarchi, Rocco Vergallo, Andrea Audo, Giulia Maj, Giuseppe Patti, Nicolas M. Van Mieghem   +9 more
wiley   +1 more source

Dual‐Function Electrocatalysis: Simultaneous Wastewater Remediation and Hydrogen Evolution—A Comprehensive Review

Carbon Energy, EarlyView.
Replacing the oxygen evolution reaction with the electro‐oxidation of pollutants and waste streams offers an energy‐efficient route for simultaneous hydrogen production and pollutant remediation. This review summarizes the reaction mechanisms, catalyst design principles, and emerging paired‐electrolysis strategies that govern activity, selectivity ...
Safa Al‐Yahyaey, Rashid Al‐Hajri, Ala'a H. Al‐Muhtaseb, Hussein A. Younus, Mohammed Al‐Abri   +4 more
wiley   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Dexmedetomidine Combined With Patient-Controlled Analgesia for Palliative Sedation in Terminal-Stage Cancer Patients With Refractory Pain: A Retrospective Analysis of Nine Cases

Pain Research and Management
Conclusion: DEX emerges as a promising option for palliative sedation in terminal-stage cancer patients. When used in conjunction with PCA, DEX has been shown to effectively, safely, and stably control refractory pain without inducing adverse effects ...
Na Li, Yumei Wang, Meng Cui
doaj   +1 more source

Predicting Responses to Electroconvulsive Therapy in Adolescents with Treatment-Refractory Depression Based on Resting-State fMRI. [PDF]

J Clin Med, 2023
Li X, Guo J, Chen X, Yu R, Chen W, Zheng A, Yu Y, Zhou D, Dai L, Kuang L.   +9 more
europepmc   +1 more source