Results 131 to 140 of about 69,860 (335)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Model and simulation of multi-functional variable refrigerant flow systems in EnergyPlus [PDF]

, 2022
María Peña, Luca Molinaroli, Barbara Torregrosa, Gaspar Paya   +3 more
openalex   +1 more source

Phase diagram and magnetocaloric effect of CoMnGe_{1-x}Sn_{x} alloys

, 2007
We propose the phase diagram of a new pseudo-ternary compound, CoMnGe_{1-x}Sn_{x}, in the range x less than or equal to 0.1. Our phase diagram is a result of magnetic and calometric measurements.
Anzai, Bazela, Castelliz, D.J. Fray, Fujieda, J.B.A. Hamer, Jeitschko, Johnson, K.G. Sandeman, Kanomata, Kaprzyk, Koyama, Lin, N.D. Mathur, Nizioł, Nizioł, Nizioł, Nizioł, Pareti, Pecharsky, Pecharsky, Provenzano, R. Daou, S. Özcan, Sandeman, Tegus, Tishin, Zach, Zimm   +28 more
core   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Recovery of Water and Salt from Hyper-Saline Mine Water using Freeze Crystallization [PDF]

, 2019
The Freezerbacks researched, designed, and economically evaluated a full-scale freeze crystallization process as well as two alternative full-scale processes: 5 stage multiple effect evaporation and reverse osmosis.
Casey, Gabrielle
core   +2 more sources

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Research on the Annual Performance Factor Differences of Inverter Air Conditioner using Different Refrigerants

Zhileng xuebao, 2019
China’s inverter air conditioner efficiency standard (GB21455—2013) adopts a single set of annual performance factor (APF) values to evaluate inverter heat-pump air conditioner charged with different types of refrigerants.
Zhu Yuxin, Li Hongqi, Wang Dongyue, Zhong Zhifeng   +3 more
doaj  

Transient refrigerant distribution in a microchannel heat exchanger heat pump system under different reverse cycle defrosting strategies

Case Studies in Thermal Engineering
The migration and redistribution of refrigerant are critical factors that affect the refrigeration system performance. To improve the defrosting and start-up heating performance, it is essential to investigate the transient distribution characteristics ...
Tong Xiong, Longxiang Hu, Guoqiang Liu, Gang Yan   +3 more
doaj   +1 more source

Boiling Refrigerant Type Compact Cooling Unit for Computer Chip. Reduction of Thermal Resistance at Boiling.

, 2001
Eitaro TANAKA, Kiyoshi Kawaguchi, Tadayoshi Terao, Masahiko Suzuki, Hiroshi Tanaka   +4 more
openalex   +2 more sources

Performance and Optimization Study of R290 as Alternative Refrigerant for R22 in Low Temperature Heat Pump System

, 2021
Yun Zhang, Cichong Liu, Wanyong Li, Junye Shi, Jiangping Chen   +4 more
openalex   +1 more source