In silico performance analysis of web tools for CRISPRa sgRNA design in human genes [PDF]
Computational and Structural Biotechnology Journal, 2022 Angiogenic gene overexpression has been the main strategy in numerous vascular regenerative gene therapy projects. However, most have failed in clinical trials.
Cristian N. Nuñez Pedrozo +6 more
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Transcriptome of Taenia solium during in vitro cyst activation and initial growth into the tapeworm stage [PDF]
Scientific DataThe cestode Taenia solium develops as a tapeworm solely in the human intestine, starting from a larva (cyst). Upon maturing, it produces hundreds of thousands of infectious eggs.
David Castaneda-Carpio +8 more
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Antibacterial Activity of AXOTL-13, a Novel Peptide Identified from the Transcriptome of the Salamander Ambystoma mexicanum [PDF]
PharmaceuticsBackground/Objectives: Antimicrobial peptides are essential molecules in the innate immunity of various organisms and possess a broad spectrum of antimicrobial, antitumor, and immunomodulatory activities. Due to their multifunctionality, they are seen as
Laura Córdoba +6 more
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Author Correction: Bile acids attenuate PKM2 pathway activation in proinflammatory microglia [PDF]
Scientific Reports, 2022 Lorenzo Romero-Ramírez +3 more
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Frontiers in Bioengineering and Biotechnology, 2021 The application of amniotic membrane (AM) on chronic wounds has proven very effective at resetting wound healing, particularly in re-epithelialization. Historically, several aspects of AM effect on wound healing have been evaluated using cell models.
Catalina Ruiz-Cañada +5 more
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Bile acids attenuate PKM2 pathway activation in proinflammatory microglia
Scientific Reports, 2022 Glycolysis is the metabolic pathway that converts glucose into pyruvate. Central nervous system (CNS) pathologies, such as spinal cord injury (SCI) and ischemia, are accompanied by an increase of the glycolytic pathway in the damaged areas as part of the
Lorenzo Romero-Ramírez +3 more
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Cells, 2020 Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-β (TFG-β).
Sergio Liarte +2 more
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Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
Cells, 2020 Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced milieu of growth factor and ...
Sergio Liarte +2 more
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Interacciones planta-animal en la regeneración de Quercus pyrenaica: ecología y gestión [PDF]
, 2014 Los rebollares de Quercus pyrenaica son formaciones casi exclusivas de la península ibérica cuya regeneración sexual se encuentra fuertemente comprometida como consecuencia de su estructura dominada por rebrotes de cepa y raíz (monte bajo).
Gil Sanchez, Luis Alfonso +2 more
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Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands
Cell Communication and Signaling, 2021 Background Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defined as Wnt/β-catenin-dependent or β-
Juan A. Godoy +2 more
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