Results 21 to 30 of about 1,340,212 (344)

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Nature, 2022
Tissue regeneration requires coordination between resident stem cells and local niche cells^ 1 , 2 . Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration at all stages of life ...
V. Moiseeva, Andrés Cisneros, V. Sica, Oleg Deryagin, Yiwei Lai, Sascha Jung, Eva Andrés, J. An, J. Segalés, L. Ortet, V. Lukesova, G. Volpe, A. Benguría, A. Dopazo, S. Benitah, Y. Urano, A. del Sol, M. Esteban, Y. Ohkawa, A. Serrano, Eusebio Perdiguero, P. Muñoz-Cánoves   +21 more
semanticscholar   +1 more source

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Military Medical Research, 2022
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury.
Y. Xiong, B. Mi, Ze Lin, Y. Hu, Le Yu, Kangkang Zha, Adriana C. Panayi, Tao Yu, Lang Chen, Zhen-Ping Liu, Anish Patel, Q. Feng, Shuanhu Zhou, Guo-hui Liu   +13 more
semanticscholar   +1 more source

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Nature Communications, 2020
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types.
M. Strunz, L. Simon, M. Ansari, J. Kathiriya, I. Angelidis, C. Mayr, George Tsidiridis, Marius Lange, L. F. Mattner, Min Yee, P. Ogar, Arunima Sengupta, I. Kukhtevich, R. Schneider, Zhongming Zhao, C. Voss, T. Stoeger, J. Neumann, A. Hilgendorff, J. Behr, M. O’Reilly, M. Lehmann, G. Burgstaller, M. Königshoff, H. Chapman, Fabian J Theis, H. Schiller   +26 more
semanticscholar   +1 more source

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Pharmaceutics, 2020
Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines.
E. M. Tottoli, R. Dorati, I. Genta, E. Chiesa, S. Pisani, B. Conti   +5 more
semanticscholar   +1 more source

The HeArt of Regeneration [PDF]

Cell, 2006
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechanisms underlying this process remain unclear. In this issue of Cell, Lipilina et al. analyze regeneration in the zebrafish heart. Their work indicates that new cardiomyocytes originate from undifferentiated progenitor cells and reveals a critical role for ...
Silvia Curado, Didier Y.R. Stainier
openaire   +3 more sources

METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation

Stem Cells International, 2023
Mesenchymal stem cells (MSCs) have been considered a potential method for the regeneration of tooth and maxillofacial bone defects based on the multidirectional differentiation characteristics of MSCs.
Xiao Han, Guoyue Li, Haoqing Yang, Chen Zhang, Yangyang Cao, Ning Wang, Lihua Ge, Zhipeng Fan   +7 more
doaj   +1 more source

Switching on regeneration [PDF]

Stem Cell Investigation, 2016
The limited ability of mammals to repair damaged tissues and organs is well known, and possibilities to improve regeneration are highly desired. Sun et al. (1) ( Cell Stem Cell , 2016) recently reported that deleting the Arid1a gene in mice greatly enhances the ability to regenerate the liver and ears after induced injury.
van der Vaart, A., van den Heuvel, Sander   +1 more
openaire   +5 more sources

Preterm birth impairs postnatal lung development in the neonatal rabbit model

Respiratory Research, 2020
Background Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical research in this area focusses on ...
Thomas Salaets, Margo Aertgeerts, André Gie, Janne Vignero, Derek de Winter, Yannick Regin, Julio Jimenez, Greetje Vande Velde, Karel Allegaert, Jan Deprest, Jaan Toelen   +10 more
doaj   +1 more source

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

Nature Communications, 2018
LncRNAs influence endothelial cell function via a number of mechanisms. Here the authors show that the lncRNA GATA6-AS regulates endothelial gene expression through interaction with the nuclear deaminase LOXL2, with functional consequences on endothelial-
Philipp Neumann, Nicolas Jaé, Andrea Knau, Simone F. Glaser, Youssef Fouani, Oliver Rossbach, Marcus Krüger, David John, Albrecht Bindereif, Phillip Grote, Reinier A. Boon, Stefanie Dimmeler   +11 more
doaj   +1 more source

A comparative study of the effects of platelet-rich fibrin, concentrated growth factor and platelet-poor plasma on the healing of tooth extraction sockets in rabbits

BMC Oral Health, 2022
Background Autologous platelet concentrate has been widely used to encourage the regeneration of hard and soft tissues. Up to now, there are three generations of autologous platelet concentrates.
Siying Li, Hongyi Yang, Qinyu Duan, Hongyu Bao, Aodi Li, Wei Li, Junliang Chen, Yun He   +7 more
doaj   +1 more source