Results 31 to 40 of about 1,340,212 (344)

Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes

open access: yesScientific Reports, 2017
Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes.
Ece Öztürk   +4 more
doaj   +1 more source

The Bone Extracellular Matrix in Bone Formation and Regeneration

open access: yesFrontiers in Pharmacology, 2020
Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties.
Xiao Lin   +3 more
semanticscholar   +1 more source

Adjuvant role of macrophages in stem cell-induced cardiac repair in rats

open access: yesExperimental and Molecular Medicine, 2018
Heart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing
Soo yeon Lim   +7 more
doaj   +1 more source

A GRF-GIF chimeric protein improves the regeneration efficiency of transgenic plants

open access: yesNature Biotechnology, 2020
The potential of genome editing to improve the agronomic performance of crops is often limited by low plant regeneration efficiencies and few transformable genotypes.
J. Debernardi   +6 more
semanticscholar   +1 more source

Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer

open access: yesNature Communications, 2023
Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords produce the neurogenic factor Hb-egfa upon transection injury.
Valentina Cigliola   +13 more
doaj   +1 more source

Cardiomyocyte Regeneration [PDF]

open access: yesCells, 2013
The heart was initially believed to be a terminally differentiated organ; once the cardiomyocytes died, no recovery could be made to replace the dead cells. However, around a decade ago, the concept of cardiac stem cells (CSCs) in adult hearts was proposed. CSCs differentiate into cardiomyocytes, keeping the heart functioning.
Toshio Nakanishi, Nanako Kawaguchi
openaire   +3 more sources

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

open access: yesActa Neuropathologica Communications, 2021
Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological ...
Yingxi Wu   +15 more
doaj   +1 more source

High Efficiency In vitro Whole Plant Regeneration via Desiccated Callus in Oryza sativa cv. MTU1010

open access: yesInternational Journal of Innovative Science and Research Technology
For most people across the planet, rice is also considered as most beneficial crops in terms of fulfilling every day's energy and nutritional needs. Worldwide food safety is seriously threatened since severe limitations on rice output caused by both ...
Anjana Priyadarshani Kanathala   +5 more
semanticscholar   +1 more source

Cardiovascular regeneration [PDF]

open access: yesStem Cell Research & Therapy, 2014
Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally considered irreversible, and can lead to lethal conditions from cardiac arrhythmias to heart failure.
openaire   +2 more sources

A high-glucose diet affects Achilles tendon healing in rats

open access: yesScientific Reports, 2017
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner   +10 more
doaj   +1 more source

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