A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
Advanced Science, 2023 Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li +16 more
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Rapid reversion from monomer to dimer regenerates the ultraviolet-B photoreceptor UV RESISTANCE LOCUS8 in intact arabidopsis plants [PDF]
, 2013 Arabidopsis (Arabidopsis thaliana) UV RESISTANCE LOCUS8 (UVR8) is a photoreceptor that specifically mediates photomorphogenic responses to ultraviolet (UV)-B in plants.
Heilmann, M., Jenkins, G.I.
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Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]
, 2020 One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J +8 more
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Acta Neuropathologica Communications, 2021 Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological ...
Yingxi Wu +15 more
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The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]
, 2015 The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio +16 more
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Cardiovascular regeneration [PDF]
Stem Cell Research & Therapy, 2014 Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally considered irreversible, and can lead to lethal conditions from cardiac arrhythmias to heart failure.
openaire +2 more sources
A high-glucose diet affects Achilles tendon healing in rats
Scientific Reports, 2017 Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner +10 more
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Entering and leaving employment in deprived neighbourhoods undergoing area regeneration [PDF]
, 2018 Concentrations of worklessness have been persistent in the UK for several decades but have not been tackled effectively by policy. An individualised approach to unemployment has existed, alongside employment policies without a strong geographical ...
Kearns, Ade, Mason, Phil
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Hospitality, Culture and Regeneration: Urban decay, entrepreneurship and the "ruin" bars of Budapest [PDF]
, 2010 This paper considers the relationships between hospitality, culture and urban regeneration through an examination of rom (ruin) venues, which operate in dilapidated buildings in Budapest, Hungary.
Amichay, E.M. +30 more
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