Results 41 to 50 of about 1,660,190 (291)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Quantum Bit Regeneration [PDF]

, 1996
Decoherence and loss will limit the practicality of quantum cryptography and computing unless successful error correction techniques are developed. To this end, we have discovered a new scheme for perfectly detecting and rejecting the error caused by ...
A. Imamoglu, B. Schumacher, G. J. Milburn, H. J. Carmichael, I. L. Chuang, Isaac L. Chuang, J. Cirac, K. Molmer, P. Shor, Q. A. Turchette, T. Cover, T. Pellizzari, V. Braginsky, W. H. Louisell, W. H. Zurek, Y. Yamamoto, Y. Yamamoto, Yoshihisa Yamamoto   +17 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A comparative study of the effects of platelet-rich fibrin, concentrated growth factor and platelet-poor plasma on the healing of tooth extraction sockets in rabbits

BMC Oral Health, 2022
Background Autologous platelet concentrate has been widely used to encourage the regeneration of hard and soft tissues. Up to now, there are three generations of autologous platelet concentrates.
Siying Li, Hongyi Yang, Qinyu Duan, Hongyu Bao, Aodi Li, Wei Li, Junliang Chen, Yun He   +7 more
doaj   +1 more source

Hospitality, Culture and Regeneration: Urban decay, entrepreneurship and the "ruin" bars of Budapest [PDF]

, 2010
This paper considers the relationships between hospitality, culture and urban regeneration through an examination of rom (ruin) venues, which operate in dilapidated buildings in Budapest, Hungary.
Amichay, E.M., Bodnár, J., Bullock, A., Csanádi, G., David Bell, Dudás, G., Edensor, T., Földes, A., Földes, A., Földes, A., Földi, Z., Johnson, L., Kirby, D.A., Kovács, Z., Krisztina Lugosi, Lashley, C., Lloyd, R., Lugosi, P., Morrison, A., Munkácsy M., Patton, M., pestcentric.com, Peter Lugosi, Pál, K., Szabo, E., Thomas, R., Thornton, S., Tracey, D., Wickham, P.A., Zukin, S., Zukin, S.   +30 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

Acta Neuropathologica Communications, 2021
Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological ...
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao   +15 more
doaj   +1 more source

Conceptualising sustainability in UK urban Regeneration: a discursive Formation [PDF]

, 2011
Despite the wide usage and popular appeal of the concept of sustainability in UK policy, it does not appear to have challenged the status quo in urban regeneration because policy is not leading in its conceptualisation and therefore implementation.
Atkinson, R., Austin Barber, BCC, BCC, BCC, BCC, BCC (Birmingham City Council), Burningham, D., Chanan, G., Chartered Institute of Housing and Royal Town Planning Institute, Chris D.F. Rogers, D. Rachel Lombardi, Daily, G., Detr, DETR (Department for Environment, Transport and the Regions), Ecotec, Edward Cullinan Architects and David McLean Developments, Ehrenfeld, J., English Partnerships, ESAG (Eastside Sustainability Advisory Group), Evans, B., Fordham, G., Haughton, G., isis, Le Heron, R., Libby Porter, Loftman, P., Loftman, P., Lovelock, J., Meadows, D.H., Millennium Assessment, Moffatt, I., Moulaert, F., NSF (National Science Foundation), Odpm, Odpm, ODPM (Office of the Deputy Prime Minister), OECD (Organisation for Economic Co-operation and Development), Owens, S., O’Riordan, T., Porter, L., PRESUD (Peer Review for European Sustainable Urban Development), Reid, D., Rydin, Y., Rydin, Y., SDC, SDC (Sustainable Development Commission), Smith, N., Swyngedouw, E., UK Government, WCED (World Commission on Environment and Development)   +50 more
core   +1 more source