Results 21 to 30 of about 157,048 (284)

Effectiveness and feasibility of a mobile health self-management intervention in rheumatoid arthritis: study protocol for a pragmatic multicentre randomised controlled trial (AEGORA)

Trials, 2023
Background Rheumatoid arthritis (RA) considerably impacts patients’ lives. Patients’ confidence in their ability to manage this impact, or self-efficacy, can be supported with self-management interventions.
Michaël Doumen, Elias De Meyst, Cedric Lefevre, Sofia Pazmino, Johan Joly, Delphine Bertrand, Mieke Devinck, René Westhovens, Patrick Verschueren   +8 more
doaj   +1 more source

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

Stem Cell Reports, 2014
Age-related macular degeneration (AMD) causes severe visual impairment due in part to age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that autologous human induced pluripotent stem cells (hiPSCs) may represent a useful
Hiroyuki Kamao, Michiko Mandai, Satoshi Okamoto, Noriko Sakai, Akiko Suga, Sunao Sugita, Junichi Kiryu, Masayo Takahashi   +7 more
doaj   +1 more source

Progenitor Cell Biology [PDF]

Archives of Neurology, 1999
A few brief years ago, damage to the central nervous system was generally perceived to be irreparable, and loss of neurons was largely viewed as an irreversible process. However, major advances in the study of neural progenitor cells have altered these perceptions, and rational approaches to the repair of the damaged nervous system using transplanted ...
John A. Kessler, Mark F. Mehler
openaire   +2 more sources

Neutrophil Chemotaxis and NETosis in Murine Chronic Liver Injury via Cannabinoid Receptor 1/Gα_i/o/ROS/p38 MAPK Signaling Pathway

Cells, 2020
Neutrophils play an essential role in the control of inflammatory diseases. However, whether cannabinoid receptors (CBs) play a role in neutrophil chemotaxis and NETosis in sterile liver inflammation remains unknown.
Xuan Zhou, Le Yang, Xiaoting Fan, Xinhao Zhao, Na Chang, Lin Yang, Liying Li   +6 more
doaj   +1 more source

Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies [PDF]

BioMed Research International, 2014
Peripheral nerve injury has perplexed neuroscientists, neurologists, plastic surgeons, and bioengineers for decades. Despite the spontaneous ability of the adult peripheral nerve system to regenerate after injury, optimal and universal treatments capable of achieving full functional recovery are still unavailable.
Xiaofeng Jia, Mario I. Romero-Ortega, Yang D. Teng   +2 more
openaire   +3 more sources

Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish

Mediators of Inflammation, 2019
As adult mammals lack the capacity to replace or repair damaged neurons, degeneration and trauma (and subsequent dysfunction) of the central nervous system (CNS) seriously constrains the patient’s life quality.
Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons   +6 more
doaj   +1 more source

Dual Targeting of Angipoietin‐1 and von Willebrand Factor by microRNA‐671‐5p Attenuates Liver Angiogenesis and Fibrosis

Hepatology Communications, 2022
Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis and progression of liver fibrosis in our previous study.
Le Yang, Wenhui Yue, Hang Zhang, Zhi Zhang, Renmin Xue, Chengbin Dong, Fuquan Liu, Na Chang, Lin Yang, Liying Li   +9 more
doaj   +1 more source

Cannabinoid Receptor 1 Participates in Liver Inflammation by Promoting M1 Macrophage Polarization via RhoA/NF-κB p65 and ERK1/2 Pathways, Respectively, in Mouse Liver Fibrogenesis

Frontiers in Immunology, 2017
Macrophage M1/M2 polarization mediates tissue damage and inflammatory responses. Cannabinoid receptor (CB) 1 participated in liver fibrogenesis by affecting bone marrow (BM)-derived monocytes/macrophages (BMMs) activation.
Lei Tian, Weiyang Li, Le Yang, Na Chang, Xiaoting Fan, Xiaofang Ji, Jieshi Xie, Lin Yang, Liying Li   +8 more
doaj   +1 more source

Endothelial progenitor cell biology in disease and tissue regeneration [PDF]

Journal of Hematology & Oncology, 2011
Abstract Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marrow niche to sites of inflammation and tumor to induce neovasculogenesis has afforded a novel opportunity to understand the ...
Shilpi Rajoria, Andrea L. George, Arulkumaran Shanmugam, Raj K. Tiwari, Robert Suriano, Pradeep Bangalore-Prakash, Abraham Mittelman   +6 more
openaire   +4 more sources

Falsely normalized ankle-brachial index despite the presence of lower-extremity peripheral artery disease: two case reports

Journal of Medical Case Reports, 2021
Background The ankle-brachial index measurement is used for screening and diagnosis of lower-extremity peripheral artery disease and cardiovascular risk assessment.
Tatsuya Maruhashi, Shogo Matsui, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Yukihito Higashi   +5 more
doaj   +1 more source