NaNog: A pluripotency homeobox (master) molecule. [PDF]
, 2015 One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE +4 more
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Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies [PDF]
BioMed Research International, 2014 Peripheral nerve injury has perplexed neuroscientists, neurologists, plastic surgeons, and bioengineers for decades. Despite the spontaneous ability of the adult peripheral nerve system to regenerate after injury, optimal and universal treatments capable of achieving full functional recovery are still unavailable.
Xiaofeng Jia +2 more
openaire +2 more sources
The role of roof plate-specific spondins in liver homeostasis and disease
Liver Research, 2022 As evolutionarily conserved signals, roof plate-specific spondins (R-spondins; RSPOs) are a family with four members (RSPO1–4) exerting distinctly different functions.
Le Yang +5 more
doaj +1 more source
The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. [PDF]
, 2015 The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species regenerative capacity.
Ahituv, Nadav +3 more
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Stem Cell Reports, 2014 Age-related macular degeneration (AMD) causes severe visual impairment due in part to age-dependent impairment of retinal pigment epithelium (RPE). It has been suggested that autologous human induced pluripotent stem cells (hiPSCs) may represent a useful
Hiroyuki Kamao +7 more
doaj +1 more source
Vascular regeneration in a basal chordate is due to the presence of immobile, bi-functional cells. [PDF]
, 2013 The source of tissue turnover during homeostasis or following injury is usually due to proliferation of a small number of resident, lineage-restricted stem cells that have the ability to amplify and differentiate into mature cell types.
Braden, Brian P +5 more
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Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]
, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin +9 more
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Studying Planarian Regeneration Aboard The International Space Station Within The Student Space Flight Experimental Program [PDF]
, 2018 The growing possibilities of space travel are quickly moving from science fiction to reality. However, to realize the dream of long-term space travel, we must understand how these conditions affect biological and physiological processes.
Bartee, C. +3 more
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Mediators of Inflammation, 2019 As adult mammals lack the capacity to replace or repair damaged neurons, degeneration and trauma (and subsequent dysfunction) of the central nervous system (CNS) seriously constrains the patient’s life quality.
Ilse Bollaerts +6 more
doaj +1 more source
Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]
, 2015 Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey +2 more
core +1 more source