Results 51 to 60 of about 157,048 (284)

The role of roof plate-specific spondins in liver homeostasis and disease

Liver Research, 2022
As evolutionarily conserved signals, roof plate-specific spondins (R-spondins; RSPOs) are a family with four members (RSPO1–4) exerting distinctly different functions.
Le Yang, Wenhui Yue, Hang Zhang, Yue Gao, Lin Yang, Liying Li   +5 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration [PDF]

Journal of Clinical Investigation, 2010
The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate ...
B. Alexander Yi, Kenneth R. Chien, Oliver Wernet   +2 more
openaire   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Treat-to-target fixed dose rituximab retreatment versus fixed interval retreatment with disease activity-guided rituximab dose optimisation for patients with rheumatoid arthritis: study protocol for a multicentre randomised controlled superiority trial focusing on long-term disease impact (RITUXERA)

Trials
Background The optimal retreatment strategy with rituximab for rheumatoid arthritis (RA) remains a point of discussion. Depending on local guidelines, rituximab can either be administered at fixed intervals or when losing disease control, balancing ...
Elias De Meyst, Delphine Bertrand, Johan Joly, Michaël Doumen, Anja Marchal, Marc Thelissen, Barbara Neerinckx, René Westhovens, Patrick Verschueren   +8 more
doaj   +1 more source

Review Article: Is Wnt Signaling an Attractive Target for the Treatment of Osteoarthritis?

Rheumatology and Therapy, 2020
Osteoarthritis is the most common chronic joint disease affecting millions of people worldwide and a leading cause of pain and disability. Increasing incidence of obesity and aging of the population are two factors that suggest that the impact of ...
Rik J. Lories, Silvia Monteagudo
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Vascular function assessed by flow-mediated vasodilation and nitroglycerine-induced vasodilation in subjects with first-degree atrioventricular block

Scientific Reports
First-degree atrioventricular block (AVB) is a common electrocardiogram finding in clinical practice. Vascular dysfunction is associated with cardiovascular disease and events. There is no information on the association of AVB with vascular function. The
Aya Mizobuchi, Tatsuya Maruhashi, Yusuke Saito, Takayuki Yamaji, Takahiro Harada, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Ayumu Nakashima, Yukihito Higashi   +9 more
doaj   +1 more source

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Cell Discovery, 2023
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to autism symptoms and macrocephaly by a ...
Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, Xiaopeng Luo, Mingtian Pan, Xiusheng Chen, Jiawei Zhang, Huijuan Xu, Xiangyu Guo, Sen Yan, Peng Yin, Zhiguang Zhao, Jianrong Liu, Yafeng Luo, Yuefeng Li, Zhengyi Yang, Baogui Zhang, Zhiqiang Tan, Hao Xu, Tianzi Jiang, Yong-hui Jiang, Shihua Li, Yong Q. Zhang, Xiao-Jiang Li   +26 more
doaj   +1 more source